{
    "assessed_biomarker_entity": "Disialylated to monosialylated O-glycoforms of hemopexin ratio(S-HPX)",
    "assessed_entity_type": "glycan|protein",
    "components": {
        "protein": [
            {
                "accession": "P02790-1",
                "name": "Hemopexin",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "27688741",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/27688741"
                    }
                ]
            }
        ],
        "glycan": [
            {
                "accession": "G90233EO",
                "evidence": [
                    {
                        "id": "GLY_000737",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000737"
                    },
                    {
                        "id": "27688741",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/27688741"
                    }
                ]
            },
            {
                "accession": "G23384FD",
                "evidence": [
                    {
                        "id": "GLY_000737",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000737"
                    },
                    {
                        "id": "27688741",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/27688741"
                    }
                ]
            }
        ]
    },
    "instances": [
        {
            "best_biomarker_type": "monitoring",
            "status": "increased S-HPX",
            "notes": "Disialylated O-glycan|GTC:G90233EO|Monosialylated O-glycan|GTC:G23384FD|Hemopexin|UPKB:P02790",
            "literature_evidence": "S-HPX, a measure of sialylated O-glycoforms of hemopexin, progressively increases in fibrotic and cirrhotic patient of HCV etiology and can be quantified by an LC-MS/MS-MRM assay in unfractionated serum of patients. Quantification of sialylated O-glycoforms of this liver secreted glycoprotein represents a novel measure of the stage of liver disease that could have a role in monitoring the progression of liver pathology. The ratio of disialylated (NeuAc2Hex1HexNAc1) to monosialylated (NeuAc1Hex1HexNAc1) glycoforms of the peptide TPLPPTSAHGNVAEGETKPDPVTER of HPX carrying one O-glycan on the T1 (S-HPX) was used as a final quantitative measure for evaluation of liver disease. The results show an approximately fourfold increase in disialylated O-glycopeptide of HPX in cirrhosis and further increase in the cirrhotics with HCC with a simultaneous approximately 20 % decrease in the monosialylated O-glycopeptide of HPX. [PMID: 27688741]",
            "loinc_code": "",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:3571",
                "recommended_name": {
                    "id": "DOID:3571",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3571",
                    "name": "liver cancer",
                    "description": "A hepatobiliary system cancer that is located_in the liver."
                },
                "synonyms": [
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "Ca liver - primary",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "Resectable malignant neoplasm of Liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "hepatic cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "hepatic neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant hepato-biliary neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant neoplasm of liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant neoplasm of liver, primary",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant tumor of liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "neoplasm of liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "non-resectable primary hepatic malignant neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "primary liver cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "primary malignant neoplasm of liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "resectable malignant neoplasm of the liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant neoplasm of liver, not specified as primary or secondary",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000737",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000737"
                },
                {
                    "id": "27688741",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/27688741"
                },
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Increased sialylation of site specific O-glycoforms of hemopexin in liver disease.",
            "journal": "Clinical proteomics",
            "authors": "Sanda Miloslav, Benicky Julius, Wu Jing, Wang Yiwen, Makambi Kepher, Ahn Jaeil, Smith Coleman I, Zhao Peng, Zhang Lihua, Goldman Radoslav",
            "date": "2016",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "27688741",
                    "url": "https://glygen.org/publication/PubMed/27688741"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000737",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000737"
                },
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
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            "id": "GLY_000737",
            "database": "GlyGen",
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        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        }
    ],
    "biomarker_id": "A0435",
    "aclist": [
        "G90233EO",
        "P02790-1",
        "G23384FD"
    ],
    "crossref": [],
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