{
    "assessed_biomarker_entity": "Lewis fucosylated triantennary N-glycan on leucine-rich alpha-2-glycoprotein-1 (LRG-FTG)",
    "assessed_entity_type": "glycan|protein",
    "components": {
        "protein": [
            {
                "accession": "P02750-1",
                "name": "Leucine-rich alpha-2-glycoprotein",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "29642865",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/29642865"
                    }
                ]
            }
        ],
        "glycan": [
            {
                "accession": "G33187NK",
                "evidence": [
                    {
                        "id": "GLY_000737",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000737"
                    },
                    {
                        "id": "29642865",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/29642865"
                    }
                ]
            }
        ]
    },
    "instances": [
        {
            "best_biomarker_type": "diagnostic",
            "status": "increased LRG-FTG level",
            "notes": "Leucine-rich alpha-2-glycoprotein-1|UPKB:P02750|A0228|Fucosylated triantennary N-glycan|GTC:G33187NK",
            "literature_evidence": "Leucine-rich alpha-2-glycoprotein-1 with fucosylated triantennary N-glycan (LRG-FTG) was identified as CRC marker after evaluating 30,000 candidate glycopeptide peaks. Serum LRG-FTG was significantly elevated in CRC patients compared with healthy volunteers, and its accuracy as a CRC tumor marker was equal to that of CEA. LRG with biantennary glycan did not change between CRC patients and healthy individuals, which meant that the sugar chain alteration in LRG was key to cancer diagnosis. The elution time (33 min) and m/z (1975.37, z4) of this marker was just coincident with leucine-rich alpha-2-glycoprotein-1, whose Asn79 was modified with fucosylated triantennary N-glycan (LRG-FTG). [PMID: 29642865]",
            "loinc_code": "",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:9256",
                "recommended_name": {
                    "id": "DOID:9256",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9256",
                    "name": "colorectal cancer",
                    "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
                },
                "synonyms": [
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "colorectal cancer",
                        "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "cancer of colorectum",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "cancer of large bowel",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "cancer of large intestine",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "cancer of the large bowel",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "colon cancer, advanced, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "colon cancer, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "colorectal cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "colorectal cancer with chromosomal instability, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "colorectal cancer, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "colorectal cancer, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "colorectum cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant colorectal neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant colorectal tumor",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant colorectal tumour",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant colorectum neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant large bowel neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant large bowel tumor",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant large bowel tumour",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant large intestine neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant large intestine tumor",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant large intestine tumour",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant neoplasm of colorectum",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant neoplasm of large bowel",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant neoplasm of large intestine",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant neoplasm of the large bowel",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant neoplasm of the large intestine",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant tumor of large bowel",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant tumor of large intestine",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant tumor of the large bowel",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant tumor of the large intestine",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant tumour of large bowel",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant tumour of large intestine",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant tumour of the large bowel",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "malignant tumour of the large intestine",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "CRC",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "colon cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0005575",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                        "name": "large intestine cancer",
                        "description": ""
                    },
                    {
                        "id": "MIM:114500",
                        "resource": "MIM",
                        "url": "https://www.omim.org/entry/114500",
                        "name": "Colorectal cancer",
                        "description": "Colorectal cancer"
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000737",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000737"
                },
                {
                    "id": "29642865",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/29642865"
                },
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Serum leucine-rich alpha-2-glycoprotein-1 with fucosylated triantennary N-glycan: a novel colorectal cancer marker.",
            "journal": "BMC cancer",
            "authors": "Shinozaki E, Tanabe K, Akiyoshi T, Tsuchida T, Miyazaki Y, Kojima N, Igarashi M, Ueno M, Suenaga M, Mizunuma N, Yamaguchi K, Nakayama K, Iijima S, Yamaguchi T",
            "date": "2018",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "29642865",
                    "url": "https://glygen.org/publication/PubMed/29642865"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000737",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000737"
                },
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000737",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000737"
        },
        {
            "id": "29642865",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/29642865"
        },
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        }
    ],
    "biomarker_id": "A0417",
    "aclist": [
        "P02750-1",
        "G33187NK"
    ],
    "crossref": [],
    "section_stats": [
        {
            "table_id": "instances",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "best_biomarker_type",
                "status",
                "notes",
                "literature_evidence",
                "loinc_code",
                "tissue.name",
                "tissue.namespace",
                "tissue.id",
                "tissue.url",
                "disease.disease_id"
            ]
        },
        {
            "table_id": "components",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}