{
    "assessed_biomarker_entity": "Sorbin and SH3 domain-containing protein 2 (SORBS2)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "O94875-1",
                "name": "Sorbin and SH3 domain-containing protein 2",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "33311452",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/33311452"
                    },
                    {
                        "id": "32905431",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/32905431"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "decreased SORBS2 level",
            "notes": "",
            "literature_evidence": "There was significantly lower expression of SORBS2 protein in metastatic tissues than that in primary tissues and normal tissues. Kaplan-Meier survival analysis indicated that patients with low SORBS2 had a poorer overall survival than those belonging to high SORBS2 levels in ccRCC. [PMID:33311452] KCNQ1OT1 and SORBS2 were elevated in DN. Both knockdown of KCNQ1OT1 and silencing of SORBS2 restrained proliferation and fibrosis and induced apoptosis in diabetic nephropathy (DN) cells. [PMID:32905431]",
            "loinc_code": "",
            "tissue": {
                "name": "kidney",
                "namespace": "UBERON",
                "id": "0002113",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002113"
            },
            "disease": {
                "disease_id": "DOID:263",
                "recommended_name": {
                    "id": "DOID:263",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:263",
                    "name": "kidney cancer",
                    "description": "A urinary system cancer that is located_in the kidney."
                },
                "synonyms": [
                    {
                        "id": "DOID:263",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:263",
                        "name": "malignant neoplasm of kidney except pelvis",
                        "description": ""
                    },
                    {
                        "id": "DOID:263",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:263",
                        "name": "malignant tumour of kidney",
                        "description": ""
                    },
                    {
                        "id": "DOID:263",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:263",
                        "name": "renal cancer",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "33311452",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/33311452"
                },
                {
                    "id": "32905431",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32905431"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "LncRNA KCNQ1OT1 affects cell proliferation, apoptosis and fibrosis through regulating miR-18b-5p/SORBS2 axis and NF-kB pathway in diabetic nephropathy.",
            "journal": "Diabetology & metabolic syndrome",
            "authors": "Jie R, Zhu P, Zhong J, Zhang Y, Wu H",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32905431",
                    "url": "https://glygen.org/publication/PubMed/32905431"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        },
        {
            "title": "RNA-binding protein SORBS2 suppresses clear cell renal cell carcinoma metastasis by enhancing MTUS1 mRNA stability.",
            "journal": "Cell death & disease",
            "authors": "Lv Q, Dong F, Zhou Y, Cai Z, Wang G",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33311452",
                    "url": "https://glygen.org/publication/PubMed/33311452"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "33311452",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/33311452"
        },
        {
            "id": "32905431",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32905431"
        }
    ],
    "biomarker_id": "A0375",
    "aclist": [
        "O94875-1"
    ],
    "crossref": [],
    "section_stats": [
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}