{
    "assessed_biomarker_entity": "Sterol regulatory element-binding protein 1 (SREBP1)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "P36956-1",
                "name": "Sterol regulatory element-binding protein 1",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
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                        "id": "31887541",
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    },
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        {
            "best_biomarker_type": "diagnostic",
            "status": "increased SREBP1 level",
            "notes": "Upregulation of SREBP1",
            "literature_evidence": "The expression of SREBP1 was significantly different among DTCs, thyroid nodules and the adjacent normal tissues. SREBP1 was upregulated follow with the malignancy. [PMID:31887541]",
            "loinc_code": "",
            "tissue": {
                "name": "thyroid gland",
                "namespace": "UBERON",
                "id": "0002046",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002046"
            },
            "disease": {
                "disease_id": "DOID:1781",
                "recommended_name": {
                    "id": "DOID:1781",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1781",
                    "name": "thyroid cancer",
                    "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                },
                "synonyms": [
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "thyroid gland cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "Thyroid gland neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "malignant neoplasm of thyroid gland",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "malignant tumour of thyroid gland",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "neoplasm of thyroid gland",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "thyroid neoplasm",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "31887541",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31887541"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "SREBP1 as a potential biomarker predicts levothyroxine efficacy of differentiated thyroid cancer.",
            "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
            "authors": "Li C, Peng X, Lv J, Zou H, Liu J, Zhang K, Li Z",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31887541",
                    "url": "https://glygen.org/publication/PubMed/31887541"
                }
            ],
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                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
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        {
            "id": "31887541",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/31887541"
        }
    ],
    "biomarker_id": "A0302",
    "aclist": [
        "P36956-1"
    ],
    "crossref": [],
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