{
    "assessed_biomarker_entity": "G protein-coupled receptor 137 (GPCR137)",
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                "name": "Parafibromin",
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                        "url": "https://data.glygen.org/GLY_000625"
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            "status": "increased GPCR137 level",
            "notes": "GPR137 is also associated with several other cancers of epithelial cells|Increased expression of G protein-coupled receptor 137",
            "literature_evidence": "The expression of GPR137 mRNA and protein in pathological tissues was significantly higher than that in adjacent normal tissues (P < .001). Moreover, similar result was found for bladder cancer patients and healthy controls (P < .001). And GPR137 expression was associated with tumor size (P = .006)  and TNM stage (P = .012). The results of Kaplan-Meier analysis suggested that patients with high expression of GPR137 had shorter overall survival time than those with low expression (Log rank test, P = .001). Cox regression analysis indicated that GPR137 could act as an independent biomarker for bladder cancer prognosis (HR = 1.850, 95% CI = 1.272-2.689, P = .001). [PMID:31464892]",
            "loinc_code": "",
            "tissue": {
                "name": "urinary bladder",
                "namespace": "UBERON",
                "id": "0001255",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001255"
            },
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                "disease_id": "DOID:11054",
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                    "name": "urinary bladder cancer",
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                },
                "synonyms": [
                    {
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                        "name": "bladder cancer",
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                    },
                    {
                        "id": "DOID:11054",
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                        "url": "http://disease-ontology.org/term/DOID:11054",
                        "name": "tumor of the bladder",
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                        "name": "urinary bladder cancer",
                        "description": "A primary or metastatic malignant neoplasm involving the bladder."
                    },
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                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "bladder cancer, somatic",
                        "description": ""
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                        "id": "MONDO:0001187",
                        "resource": "MONDO",
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                        "name": "cancer of urinary bladder",
                        "description": ""
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                        "name": "malignant bladder neoplasm",
                        "description": ""
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                    {
                        "id": "MONDO:0001187",
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                        "name": "malignant bladder tumor",
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                    {
                        "id": "MONDO:0001187",
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                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "malignant bladder tumour",
                        "description": ""
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                    {
                        "id": "MONDO:0001187",
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                        "id": "MONDO:0001187",
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                    {
                        "id": "MONDO:0001187",
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                    {
                        "id": "MONDO:0001187",
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                    },
                    {
                        "id": "MONDO:0001187",
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                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "urinary bladder malignant tumor",
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                    },
                    {
                        "id": "MONDO:0001187",
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                        "name": "urinary bladder malignant tumour",
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                    },
                    {
                        "id": "MIM:109800",
                        "resource": "MIM",
                        "url": "https://www.omim.org/entry/109800",
                        "name": "Bladder cancer",
                        "description": "Bladder cancer"
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
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                    "id": "31464892",
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    "publication": [
        {
            "title": "GPR137 is a promising novel bio-marker for the prognosis of bladder cancer patients.",
            "journal": "Medicine",
            "authors": "Lu J, Zhong F, Sun B, Wang C",
            "date": "2019",
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