{
    "assessed_biomarker_entity": "Interleukin-18 (IL18)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "Q14116-1",
                "name": "Interleukin-18",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "32576222",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/32576222"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "monitoring",
            "status": "increased IL18 level",
            "notes": "Measured in serum (UN:0001977) as well.",
            "literature_evidence": "Levels of VEGF-D, TNF-alpha, SCF, LIF, IL-2, IL-4, IL-6, IL-8, IL-10, IL-15, IL-17A, IL-18, IL-1 beta, and IFN-gamma were significantly higher in the critical group than in the severe group (Table 1). [PMID:32576222]",
            "loinc_code": "33823-6",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:0080600",
                "recommended_name": {
                    "id": "DOID:0080600",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080600",
                    "name": "COVID-19",
                    "description": "A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2."
                },
                "synonyms": [
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019 Novel Coronavirus (2019-nCoV)",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019-nCoV infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan coronavirus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan seafood market pneumonia virus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "COVID19",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "SARS-CoV-2 infection",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "32576222",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32576222"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "VEGF-D: a novel biomarker for detection of COVID-19 progression.",
            "journal": "Critical care (London, England)",
            "authors": "Kong Y, Han J, Wu X, Zeng H, Liu J, Zhang H",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32576222",
                    "url": "https://glygen.org/publication/PubMed/32576222"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "32576222",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32576222"
        }
    ],
    "biomarker_id": "A0150",
    "aclist": [
        "Q14116-1"
    ],
    "crossref": [],
    "section_stats": [
        {
            "table_id": "instances",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "best_biomarker_type",
                "status",
                "notes",
                "literature_evidence",
                "loinc_code",
                "tissue.name",
                "tissue.namespace",
                "tissue.id",
                "tissue.url",
                "disease.disease_id"
            ]
        },
        {
            "table_id": "components",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
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                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}