{
    "assessed_biomarker_entity": "Myoglobin (MB)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "P02144-1",
                "name": "Myoglobin",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "32450473",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/32450473"
                    },
                    {
                        "id": "32305557",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/32305557"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "increased MB level",
            "notes": "Measured in serum (UN:0001977) as well.",
            "literature_evidence": "An increased concentration of myoglobin was associated with an increased risk of hospitalization mortality in non-survivors with NCIP. In conclusion, our study provides important documentation that in this single-center, an elevated serum concentration of myoglobin (>/=306.5 ug/L) is associated with an increased risk of hospitalization mortality in non-survivor with NCIP, independent of elevation in CK-MB and Troponin I levels. [PMID:32450473]",
            "loinc_code": "2639-3",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:0080600",
                "recommended_name": {
                    "id": "DOID:0080600",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080600",
                    "name": "COVID-19",
                    "description": "A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2."
                },
                "synonyms": [
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019 Novel Coronavirus (2019-nCoV)",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019-nCoV infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan coronavirus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan seafood market pneumonia virus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "COVID19",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "SARS-CoV-2 infection",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "32450473",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32450473"
                },
                {
                    "id": "32305557",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32305557"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "The impact of 2019 novel coronavirus on heart injury: A Systematic review and Meta-analysis.",
            "journal": "Progress in cardiovascular diseases",
            "authors": "Li JW, Han TW, Woodward M, Anderson CS, Zhou H, Chen YD, Neal B",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32305557",
                    "url": "https://glygen.org/publication/PubMed/32305557"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        },
        {
            "title": "Elevated cardiac biomarkers are associated with increased mortality for inpatients with COVID-19: A retrospective case-control study.",
            "journal": "Journal of clinical anesthesia",
            "authors": "Su M, Wang Y, Peng J, Wu MJ, Deng W, Yang YS",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32450473",
                    "url": "https://glygen.org/publication/PubMed/32450473"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "32450473",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32450473"
        },
        {
            "id": "32305557",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32305557"
        }
    ],
    "biomarker_id": "A0103",
    "aclist": [
        "P02144-1"
    ],
    "crossref": [],
    "section_stats": [
        {
            "table_id": "instances",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "best_biomarker_type",
                "status",
                "notes",
                "literature_evidence",
                "loinc_code",
                "tissue.name",
                "tissue.namespace",
                "tissue.id",
                "tissue.url",
                "disease.disease_id"
            ]
        },
        {
            "table_id": "components",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}
