{
    "assessed_biomarker_entity": "Surfactant protein A (SFTPA1)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "Q8IWL2-1",
                "name": "Pulmonary surfactant-associated protein A1",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "increased SFTPA1 level",
            "notes": "Measured in serum (UN:0001977) as well.",
            "literature_evidence": "Serum SP-A and SP-D levels were significantly higher in severe cases than in non severe cases. Additionally, SP-A was higher in non-severe cases than in healthy subjects. We propose that serum SP-A and SP-D level might be useful as biomarkers of COVID-19 pneumonia severity. [DOI:10.21203/rs.3.rs-29567/v1]",
            "loinc_code": "",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:0080600",
                "recommended_name": {
                    "id": "DOID:0080600",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080600",
                    "name": "COVID-19",
                    "description": "A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2."
                },
                "synonyms": [
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019 Novel Coronavirus (2019-nCoV)",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019-nCoV infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan coronavirus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan seafood market pneumonia virus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "COVID19",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "SARS-CoV-2 infection",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "10.21203/rs.3.rs-29567/v1",
                    "database": "DOI",
                    "url": "https://glygen.org/publication/DOI/10.21203/rs.3.rs-29567/v1"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Serum surfactant protein A and D may be novel biomarkers of COVID-19 pneumonia severity",
            "journal": "Preprint at Research Square",
            "authors": "Saito A., Kuronuma K., Moniwa K., Kodama K., Takahashi S., Takahashi H., Chiba H.",
            "date": "2020",
            "reference": [
                {
                    "type": "DOI",
                    "id": "10.21203/rs.3.rs-29567/v1",
                    "url": "https://glygen.org/publication/DOI/10.21203/rs.3.rs-29567/v1"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "10.21203/rs.3.rs-29567/v1",
            "database": "DOI",
            "url": "https://glygen.org/publication/DOI/10.21203/rs.3.rs-29567/v1"
        }
    ],
    "biomarker_id": "A0095",
    "aclist": [
        "Q8IWL2-1"
    ],
    "crossref": [],
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}