{
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    "number_monosaccharides_suffix": "",
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        "gnome_glygen_nglycans": "no",
        "gnome_glycotree_nglycans": "no"
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    "inchi_key": {
        "key": "XBSNXOHQOTUENA-UQTBNESHSA-N",
        "url": "https://pubchem.ncbi.nlm.nih.gov/compound/XBSNXOHQOTUENA-UQTBNESHSA-N"
    },
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            "type": {
                "name": "Other",
                "url": ""
            },
            "subtype": {
                "name": "Other",
                "url": ""
            }
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            "name": "Methyl",
            "residue": "me",
            "count": 0
        },
        {
            "name": "N-Acetyl-Neuraminic Acid",
            "residue": "neuac",
            "count": 1,
            "cid": "439197",
            "url": "https://pubchem.ncbi.nlm.nih.gov/compound/439197"
        },
        {
            "name": "N-Glycolyl-Neuraminic Acid",
            "residue": "neugc",
            "count": 0,
            "cid": "440001",
            "url": "https://pubchem.ncbi.nlm.nih.gov/compound/440001"
        },
        {
            "name": "Phosphate",
            "residue": "p",
            "count": 0,
            "cid": "1061",
            "url": "https://pubchem.ncbi.nlm.nih.gov/compound/1061"
        },
        {
            "name": "Pentose",
            "residue": "pent",
            "count": 0,
            "cid": "229",
            "url": "https://pubchem.ncbi.nlm.nih.gov/compound/229"
        },
        {
            "name": "Sulfate",
            "residue": "s",
            "count": 0,
            "cid": "1117",
            "url": "https://pubchem.ncbi.nlm.nih.gov/compound/1117"
        },
        {
            "name": "Sialic acid",
            "residue": "sia",
            "count": 1,
            "cid": "906",
            "url": "https://pubchem.ncbi.nlm.nih.gov/compound/906"
        },
        {
            "name": "Other",
            "residue": "other",
            "count": 0
        },
        {
            "name": "Floating substituent",
            "residue": "x",
            "count": 0
        },
        {
            "name": "D-Xylose",
            "residue": "xyl",
            "count": 0,
            "cid": "135191",
            "url": "https://pubchem.ncbi.nlm.nih.gov/compound/135191"
        },
        {
            "name": "Ketodeoxynononic acid",
            "residue": "kdn",
            "count": 0,
            "cid": "13991616",
            "url": "https://pubchem.ncbi.nlm.nih.gov/compound/13991616"
        }
    ],
    "motifs": [
        {
            "id": "GGM.000005",
            "name": "Type 1 LN",
            "synonym": "",
            "keywords": "LacNAc; N-acetyllactosamine; N-acetyllactosamine type 1"
        },
        {
            "id": "GGM.000020",
            "name": "Lewis a",
            "synonym": "Le^a; Lea",
            "keywords": "Lewis a"
        },
        {
            "id": "GGM.000024",
            "name": "Sialyl Lewis a",
            "synonym": "CA19-9 antigen; SLe^a; SLea; Slea",
            "keywords": "Lewis a"
        }
    ],
    "interactions": [],
    "expression": [],
    "subsumption": [
        {
            "related_accession": "G01010HI",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G01050MH",
            "relationship": "ancestor"
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        {
            "related_accession": "G05917SW",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G11499FP",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G12750SG",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G12942ZN",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G13065CP",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G15602PX",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G16258KS",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G16340GB",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G16746MI",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G16918PH",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G18300TG",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G22933CR",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G25705KO",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G42932DS",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G43415ON",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G58879PQ",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G66768WN",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G68569PY",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G81971FM",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G88197GR",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G88888LR",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G89752BK",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G94360ZY",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G95160NQ",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G98896IU",
            "relationship": "ancestor"
        },
        {
            "related_accession": "G42932DS",
            "relationship": "basecomposition"
        },
        {
            "related_accession": "G58879PQ",
            "relationship": "composition"
        },
        {
            "related_accession": "G16746MI",
            "relationship": "subsumedby"
        },
        {
            "related_accession": "G81971FM",
            "relationship": "subsumedby"
        },
        {
            "related_accession": "G12750SG",
            "relationship": "topology"
        }
    ],
    "names": [],
    "keywords": [
        "fully_determined"
    ],
    "glycotree_pathways": [],
    "dictionary": {
        "term": "Sialyl Lewis a",
        "term_in_sentence": "By comparing the serum O-glycan profiles from healthy controls with those of cancer patients, we identified a marker candidate, core 1 sialyl Lewis A (NeuAc\u03b12-3Gal\u03b21-3(Fuc\u03b11-4)GlcNAc\u03b21-3Gal) (abbreviated C1SLA), whose concentration appeared to be weakly correlated with CA19-9 values.[PMID:26641888]",
        "publication": "26641888|31424423|26530370|17760270|18343410|16033091|8829184|11907351|20592391|26641888|24128856|30249386|10773785|16149606|10996727|10436809|10667238|7720892|7630017|10612415|9836451|12511721|22623153",
        "definition": "A sialyated version of Lewis A with a branched structure of amino tetrasaccharide consisting of a sialyl residue, linked (2\u21923) to a galactosyl residue that in turn is linked (1\u21923) to a glucosaminyl residue at the reducing end, which is also carrying a fucosyl residue at the 4-position.[CHEBI:62681]",
        "term_xref": "GTC:G00053MO|GlycoEpitope:EP0008|CID:53356732|CHEBI:62681|GlycoMotif:GGM.000024",
        "synonymns": [
            "SLea",
            "CA19-9",
            "CA19-9 antigen",
            "SLe^a",
            "Slea"
        ],
        "function": "The carbohydrate determinants,Sialyl Lea and Sialyl Lex,which are frequently expressed on human cancer cells,serve as ligands for a cell adhesion molecule of the selectin family,E-selectin,which is expressed on vascular endothelial cells. These carbohydrate determinants are involved in the adhesion of cancer cells to vascular endothelium and thus contribute to hematogenous metastasis of cancer.[GlycoEpitope:EP0008]",
        "disease_associations": "pancreatic adenocarcinoma[GlycoEpitope:EP0008]|hepatocellular cancer[GlycoEpitope:EP0008]|cholangiocellular cancer[GlycoEpitope:EP0008]|gastric cancer|[GlycoEpitope:EP0008]colorectal cancer[GlycoEpitope:EP0008]|ovarian cancer[GlycoEpitope:EP0008]|lung cancer[GlycoEpitope:EP0008]|breast cancer[GlycoEpitope:EP0008]|uterine cancer[GlycoEpitope:EP0008]",
        "wikipedia": "",
        "essentials_of_glycobiology": "",
        "evidence": [
            {
                "id": "GSD000150",
                "url": "https://wiki.glygen.org/Glycan_structure_dictionary#GSD000150",
                "database": "Glycan Structure Dictionary"
            }
        ]
    }
}