{
    "bcoid": "GLY_000597",
    "title": "Human UniProtKB Xref Rhea",
    "description": "The Human UniProtKB Xref Rhea contains human [taxid:9606] UniProtKB canonical accessions cross-referenced ...",
    "filename": "human_protein_xref_rhea.csv",
    "filetype": "csv",
    "categories": {
        "species": [
            "Homo sapiens"
        ],
        "molecule": [
            "Protein"
        ],
        "tag": [
            "Rhea cross-references"
        ],
        "file_type": [
            "csv"
        ],
        "status": [
            "Reviewed"
        ],
        "scope": [
            "internal"
        ]
    },
    "minitable": {
        "content": [
            [
                "P30613-1...",
                "protein_xref..."
            ],
            [
                "Q96J66-1...",
                "protein_xref..."
            ]
        ],
        "headers": [
            "uniprotkb_ca...",
            "xref_key..."
        ],
        "colwidth": [
            "40%",
            "20%"
        ]
    },
    "sampledata": {
        "type": "table",
        "data": [
            [
                {
                    "type": "string",
                    "label": "uniprotkb_canonical_ac"
                },
                {
                    "type": "string",
                    "label": "xref_key"
                },
                {
                    "type": "string",
                    "label": "xref_id"
                },
                {
                    "type": "string",
                    "label": "xref_label"
                }
            ],
            [
                "P30613-1",
                "protein_xref_rhea",
                "18157",
                "ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate"
            ],
            [
                "Q96J66-1",
                "protein_xref_rhea",
                "19121",
                "an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate"
            ],
            [
                "Q96J66-1",
                "protein_xref_rhea",
                "38963",
                "ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate"
            ],
            [
                "Q96J66-1",
                "protein_xref_rhea",
                "50052",
                "ATP + H2O + taurocholate(in) = ADP + H(+) + phosphate + taurocholate(out)"
            ],
            [
                "Q96J66-1",
                "protein_xref_rhea",
                "50056",
                "ATP + glycocholate(in) + H2O = ADP + glycocholate(out) + H(+) + phosphate"
            ],
            [
                "Q96J66-1",
                "protein_xref_rhea",
                "60128",
                "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate"
            ],
            [
                "Q96J66-1",
                "protein_xref_rhea",
                "61348",
                "ATP + estrone 3-sulfate(in) + H2O = ADP + estrone 3-sulfate(out) + H(+) + phosphate"
            ],
            [
                "Q96J66-1",
                "protein_xref_rhea",
                "61364",
                "ATP + dehydroepiandrosterone 3-sulfate(in) + H2O = ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate"
            ],
            [
                "Q96J66-1",
                "protein_xref_rhea",
                "66184",
                "3',5'-cyclic AMP(in) + ATP + H2O = 3',5'-cyclic AMP(out) + ADP + H(+) + phosphate"
            ],
            [
                "Q96J66-1",
                "protein_xref_rhea",
                "66188",
                "3',5'-cyclic GMP(in) + ATP + H2O = 3',5'-cyclic GMP(out) + ADP + H(+) + phosphate"
            ],
            [
                "Q96J66-1",
                "protein_xref_rhea",
                "61380",
                "2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O = 2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate"
            ],
            [
                "P53779-1",
                "protein_xref_rhea",
                "17989",
                "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]"
            ],
            [
                "P53779-1",
                "protein_xref_rhea",
                "46608",
                "ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]"
            ],
            [
                "Q969W1-1",
                "protein_xref_rhea",
                "36683",
                "hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]"
            ],
            [
                "Q13228-1",
                "protein_xref_rhea",
                "11812",
                "H2O + methanethiol + O2 = formaldehyde + H(+) + H2O2 + hydrogen sulfide"
            ],
            [
                "P41250-1",
                "protein_xref_rhea",
                "16013",
                "ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)"
            ],
            [
                "P41250-1",
                "protein_xref_rhea",
                "34935",
                "2 ATP + H(+) = diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate"
            ],
            [
                "Q01813-1",
                "protein_xref_rhea",
                "16109",
                "ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)"
            ],
            [
                "Q9UHL0-1",
                "protein_xref_rhea",
                "13065",
                "ATP + H2O = ADP + H(+) + phosphate"
            ],
            [
                "Q9Y295-1",
                "protein_xref_rhea",
                "19669",
                "GTP + H2O = GDP + H(+) + phosphate"
            ],
            [
                "O15294-1",
                "protein_xref_rhea",
                "48908",
                "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP"
            ],
            [
                "Q8IYD1-1",
                "protein_xref_rhea",
                "19669",
                "GTP + H2O = GDP + H(+) + phosphate"
            ],
            [
                "Q8IYD8-1",
                "protein_xref_rhea",
                "13065",
                "ATP + H2O = ADP + H(+) + phosphate"
            ],
            [
                "P24903-1",
                "protein_xref_rhea",
                "17149",
                "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"
            ],
            [
                "Q9P0Z9-1",
                "protein_xref_rhea",
                "13313",
                "H2O + O2 + sarcosine = formaldehyde + glycine + H2O2"
            ],
            [
                "Q9NV23-1",
                "protein_xref_rhea",
                "15057",
                "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP]"
            ],
            [
                "Q9NV23-1",
                "protein_xref_rhea",
                "16645",
                "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate"
            ],
            [
                "Q9NV23-1",
                "protein_xref_rhea",
                "30135",
                "dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+)"
            ],
            [
                "Q9NV23-1",
                "protein_xref_rhea",
                "40059",
                "decanoyl-CoA + H2O = CoA + decanoate + H(+)"
            ],
            [
                "Q9NV23-1",
                "protein_xref_rhea",
                "40119",
                "H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate"
            ],
            [
                "P45984-1",
                "protein_xref_rhea",
                "17989",
                "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]"
            ],
            [
                "P45984-1",
                "protein_xref_rhea",
                "46608",
                "ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]"
            ],
            [
                "Q9H237-1",
                "protein_xref_rhea",
                "45336",
                "(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine = [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA"
            ],
            [
                "Q8WVX9-1",
                "protein_xref_rhea",
                "52716",
                "a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)"
            ],
            [
                "Q8WVX9-1",
                "protein_xref_rhea",
                "36315",
                "2 H(+) + hexadecanoyl-CoA + 2 NADPH = CoA + hexadecan-1-ol + 2 NADP(+)"
            ],
            [
                "Q8WVX9-1",
                "protein_xref_rhea",
                "36319",
                "2 H(+) + 2 NADPH + octadecanoyl-CoA = CoA + 2 NADP(+) + octadecan-1-ol"
            ],
            [
                "O60832-1",
                "protein_xref_rhea",
                "47036",
                "uridine in 5S rRNA = pseudouridine in 5S rRNA"
            ],
            [
                "P48506-1",
                "protein_xref_rhea",
                "13285",
                "ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate"
            ],
            [
                "O00116-1",
                "protein_xref_rhea",
                "36171",
                "a 1-acylglycerone 3-phosphate + a long chain fatty alcohol = 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)"
            ],
            [
                "P17900-1",
                "protein_xref_rhea",
                "39747",
                "cholesterol(in) = cholesterol(out)"
            ],
            [
                "Q9NPI5-1",
                "protein_xref_rhea",
                "14017",
                "ATP + beta-nicotinamide D-riboside = ADP + beta-nicotinamide D-ribonucleotide + H(+)"
            ],
            [
                "Q9NPI5-1",
                "protein_xref_rhea",
                "25568",
                "ATP + beta-D-ribosylnicotinate = ADP + H(+) + nicotinate beta-D-ribonucleotide"
            ],
            [
                "Q9NPI6-1",
                "protein_xref_rhea",
                "67484",
                "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP"
            ],
            [
                "Q05397-1",
                "protein_xref_rhea",
                "10596",
                "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]"
            ],
            [
                "Q96LT4-1",
                "protein_xref_rhea",
                "42128",
                "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine"
            ],
            [
                "Q96LT4-1",
                "protein_xref_rhea",
                "42144",
                "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine"
            ],
            [
                "Q53H12-1",
                "protein_xref_rhea",
                "10272",
                "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)"
            ],
            [
                "Q53H12-1",
                "protein_xref_rhea",
                "17929",
                "an N-acylsphing-4-enine + ATP = ADP + an N-acylsphing-4-enine 1-phosphate + H(+)"
            ],
            [
                "Q53H12-1",
                "protein_xref_rhea",
                "19293",
                "a monoacylglycerol + ATP = ADP + H(+) + monoacyl-sn-glycero-3-phosphate"
            ],
            [
                "Q53H12-1",
                "protein_xref_rhea",
                "33747",
                "a 1-acyl-sn-glycerol + ATP = a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)"
            ],
            [
                "Q53H12-1",
                "protein_xref_rhea",
                "40327",
                "1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"
            ],
            [
                "Q53H12-1",
                "protein_xref_rhea",
                "41079",
                "1-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"
            ],
            [
                "Q53H12-1",
                "protein_xref_rhea",
                "43308",
                "1-hexadecanoyl-sn-glycerol + ATP = 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)"
            ],
            [
                "Q53H12-1",
                "protein_xref_rhea",
                "43312",
                "ATP + N-(hexanoyl)sphing-4-enine = ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate"
            ],
            [
                "Q53H12-1",
                "protein_xref_rhea",
                "43316",
                "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"
            ],
            [
                "Q53H12-1",
                "protein_xref_rhea",
                "43328",
                "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"
            ],
            [
                "Q13557-1",
                "protein_xref_rhea",
                "17989",
                "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]"
            ],
            [
                "Q13557-1",
                "protein_xref_rhea",
                "46608",
                "ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]"
            ],
            [
                "Q96AQ7-1",
                "protein_xref_rhea",
                "39011",
                "a triacyl-sn-glycerol(in) = a triacyl-sn-glycerol(out)"
            ],
            [
                "Q6P1M0-1",
                "protein_xref_rhea",
                "15421",
                "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate"
            ],
            [
                "Q6P1M0-1",
                "protein_xref_rhea",
                "19713",
                "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate"
            ],
            [
                "Q6P1M0-1",
                "protein_xref_rhea",
                "30751",
                "ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA"
            ],
            [
                "Q6P1M0-1",
                "protein_xref_rhea",
                "33607",
                "(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate"
            ],
            [
                "Q6P1M0-1",
                "protein_xref_rhea",
                "33639",
                "ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoA"
            ],
            [
                "Q6P1M0-1",
                "protein_xref_rhea",
                "36139",
                "(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate"
            ],
            [
                "Q6P1M0-1",
                "protein_xref_rhea",
                "38879",
                "a fatty acid(in) = a fatty acid(out)"
            ],
            [
                "Q6P1M0-1",
                "protein_xref_rhea",
                "54536",
                "a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate"
            ],
            [
                "Q6P1M0-1",
                "protein_xref_rhea",
                "33655",
                "(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in)"
            ],
            [
                "Q6P1M0-1",
                "protein_xref_rhea",
                "45256",
                "hexadecanoate(out) = hexadecanoate(in)"
            ],
            [
                "Q6P1M0-1",
                "protein_xref_rhea",
                "45264",
                "(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)-octadecadienoate(in)"
            ],
            [
                "Q8TED1-1",
                "protein_xref_rhea",
                "16833",
                "2 glutathione + H2O2 = glutathione disulfide + 2 H2O"
            ],
            [
                "Q8TED4-1",
                "protein_xref_rhea",
                "71535",
                "D-glucose 6-phosphate(in) + phosphate(out) = D-glucose 6-phosphate(out) + phosphate(in)"
            ],
            [
                "O43598-1",
                "protein_xref_rhea",
                "51132",
                "a purine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a purine nucleobase"
            ],
            [
                "O43598-1",
                "protein_xref_rhea",
                "57852",
                "a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase"
            ],
            [
                "P60891-1",
                "protein_xref_rhea",
                "15609",
                "ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)"
            ],
            [
                "P21964-1",
                "protein_xref_rhea",
                "17877",
                "a catechol + S-adenosyl-L-methionine = a guaiacol + H(+) + S-adenosyl-L-homocysteine"
            ],
            [
                "P21964-1",
                "protein_xref_rhea",
                "53088",
                "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"
            ],
            [
                "P21964-1",
                "protein_xref_rhea",
                "53092",
                "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"
            ],
            [
                "P21964-1",
                "protein_xref_rhea",
                "53096",
                "4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"
            ],
            [
                "P21964-1",
                "protein_xref_rhea",
                "53100",
                "2-hydroxyestrone + S-adenosyl-L-methionine = 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine"
            ],
            [
                "P21964-1",
                "protein_xref_rhea",
                "53104",
                "4-hydroxyestrone + S-adenosyl-L-methionine = 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine"
            ],
            [
                "P21964-1",
                "protein_xref_rhea",
                "53108",
                "2-hydroxyestrone + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine"
            ],
            [
                "Q6P988-1",
                "protein_xref_rhea",
                "45340",
                "[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O = (9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+)"
            ],
            [
                "P14324-1",
                "protein_xref_rhea",
                "19361",
                "(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate"
            ]
        ]
    },
    "readme": "Name\n   - Human UniProtKB Xref Rhea\n\nVersion\n   - v-2.2.1\n\nCreated on\n  - 2021-10-15T06:33:28.159541\n\nModified on\n   - 2022-09-26T09:08:12.706789\n\nCreated by\n   -  [jeetvora@gwu.edu], Karina Martinez [karinamartinez@gwu.edu], Jingyue Wu [jingyue.wu@email.gwu.edu]\n\nAuthors\n   - Not Applicable []\n\nChecksum\n   - \n\nUsability Domain\n   - The Human UniProtKB Xref Rhea contains human [taxid:9606] UniProtKB canonical accessions cross-referenced to Rhea database accessions/identifiers. The dataset is derived from 2019-09 UniProtKB release. If you use this dataset please provide proper attribution to EMBL-EBI-UniProtKB and GlyGen. \n   - Rhea\n\nDescription Domain\n   Keywords\n   - reactions\n   - Rhea\n   - cross-reference\n\n   Pipeline Steps\n   - Step-1: The script loads the UniProtKB canonical accessions that are cross-referenced to Rhea database accessions/identifiers from the triplestore containing triples from nt file and extracts the data as a csv dataset. \n\nExecution Domain\n   Scripts   - https://github.com/glygener/glygen-backend-integration/blob/master/dataset-maker/make-protein-dataset.py\n\n\n   Software Prerequisites\n      Name: Python\n      Version: 2.7.5\n      URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n   Input Subdomain\n      Name: uniprot-proteome-homo-sapiens.nt\n      URI: https:/data.glygen.org/ln2downloads/ebi/2023_10_30/uniprot-proteome-homo-sapiens.nt\n   Output Subdomain\n      Name: human_protein_xref_rhea.csv\n      URI: https:/data.glygen.org/ln2releases/data/v-2.2.1/reviewed/human_protein_xref_rhea.csv\n      Name: human_protein_xref_rhea.stat.csv\n      URI: https:/data.glygen.org/ln2releases/data/v-2.2.1/reviewed/human_protein_xref_rhea.stat.csv\n\nFields\n      Name: \"uniprotkb_canonical_ac\"\n     Description: \"\"\n      Unique Values: \"3536\"\n      Name: \"xref_key\"\n     Description: \"Source key associated to the  xref_id\"\n      Unique Values: \"1\"\n      Name: \"xref_id\"\n     Description: \"ID of the X-ref\"\n      Unique Values: \"4951\"\n      Name: \"xref_label\"\n     Description: \"Label/Name associated with x-ref\"\n      Unique Values: \"4951\"",
    "downloadurl": "/ln2data/releases/data/v-2.2.1/reviewed/human_protein_xref_rhea.csv"
}