{
    "assessed_biomarker_entity": "miRNA-9-3 gene (MIR-9-3)",
    "assessed_entity_type": "gene",
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                "accession": "Q6P1J9-1",
                "name": "Parafibromin",
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                        "url": "https://data.glygen.org/GLY_000625"
                    },
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        "glycan": []
    },
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            "best_biomarker_type": "prognostic",
            "status": "hypermethylated MIR-9-3 gene",
            "notes": "",
            "literature_evidence": "...five microRNA genes (MIR-9-1, MIR-9-3, MIR-107, MIR-1258, and MIR-130b) methylated in the majority of tumor specimens in comparison with paired specimens of histologically intact tissue (37-57% vs. 4-9%, p<0.01). Methylation of three genes (MIR-9-1, MIR-9-3, and MIR-130b) was significantly (p\u22640.05) associated with the parameters of ovarian cancer progress (clinical stage, differentiation degree, tumor size, and presence of metastases). These findings attest to oncosuppressive role of the studied microRNA genes (MIR-9-1, MIR-9-3, MIR-107, MIR-1258, and MIR-130b) in the pathogenesis and progress of ovarian cancer and indicated their prognostic potential. [PMID:29313235]",
            "loinc_code": "",
            "tissue": {
                "name": "ovary",
                "namespace": "UBERON",
                "id": "0000992",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000992"
            },
            "disease": {
                "disease_id": "DOID:2394",
                "recommended_name": {
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                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2394",
                    "name": "ovarian cancer",
                    "description": "A female reproductive organ cancer that is located_in the ovary."
                },
                "synonyms": [
                    {
                        "id": "DOID:2394",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:2394",
                        "name": "malignant Ovarian tumor",
                        "description": ""
                    },
                    {
                        "id": "DOID:2394",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:2394",
                        "name": "malignant tumour of ovary",
                        "description": ""
                    },
                    {
                        "id": "DOID:2394",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:2394",
                        "name": "ovarian neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:2394",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:2394",
                        "name": "ovary neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:2394",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:2394",
                        "name": "primary ovarian cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:2394",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:2394",
                        "name": "tumor of the Ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0011931",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                        "name": "ovarian cancer, susceptibility to, 1",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0011931",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                        "name": "OVCAS1",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0011931",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                        "name": "ovarian cancer, susceptibility to",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0011931",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                        "name": "ovarian cancer, susceptibility to, 1",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovarian cancer",
                        "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas."
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovarian neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovary neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
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                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "tumor of the ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "cancer of ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
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                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "cancer of the ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant neoplasm of ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant neoplasm of the ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant ovarian neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant ovarian tumor",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant ovary neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant tumor of ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant tumor of the ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant tumour of ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovarian cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovarian cancer, somatic",
                        "description": ""
                    },
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                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
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                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovary cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovarian cancer, epithelial",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "primary ovarian cancer",
                        "description": ""
                    },
                    {
                        "id": "MIM:167000",
                        "resource": "MIM",
                        "url": "https://www.omim.org/entry/167000",
                        "name": "Ovarian cancer",
                        "description": "Ovarian cancer"
                    }
                ]
            },
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                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "29313235",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/29313235"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Five Hypermethylated MicroRNA Genes as Potential Markers of Ovarian Cancer.",
            "journal": "Bulletin of experimental biology and medicine",
            "authors": "Braga E A, Loginov V I, Burdennyi A M, Filippova E A, Pronina I V, Kurevlev S V, Kazubskaya T P, Kushlinskii D N, Utkin D O, Ermilova V D, Kushlinskii N E",
            "date": "2018-01",
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                {
                    "type": "PubMed",
                    "id": "29313235",
                    "url": "https://glygen.org/publication/PubMed/29313235"
                }
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                }
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        }
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        }
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    ],
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