{
    "assessed_biomarker_entity": "Man6 high mannose N-glycan (F0H6N2S0)",
    "assessed_entity_type": "glycan",
    "components": {
        "protein": [],
        "glycan": [
            {
                "accession": "G80966KZ",
                "evidence": [
                    {
                        "id": "GLY_000737",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000737"
                    },
                    {
                        "id": "30889355",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/30889355"
                    }
                ]
            }
        ]
    },
    "instances": [
        {
            "best_biomarker_type": "diagnostic",
            "status": "increased F0H6N2S0 level",
            "notes": "",
            "literature_evidence": "In comparing the N-glycan profiles of healthy individuals with those suffering from breast cancer, six N-glycans with AUC greater than 0.9 indicated excellent diagnostic accuracy (Figure 4). Of those, two bisected N-glycans (F0H4N5S0 and F1H4N5S0, Figure 4A,B) exhibited decreased relative abundances, while the other four N-glycans included three high-mannose N-glycans (F0H6N2S0, F0H7N2S0, and F0H8N2S0, Figure 4C,D,E), and fucosylated glycan (F1H3N2S0, Figure 4F) exhibited increased relative abundances. Overall, three high-mannose N-glycans (F0H6N2S0, F0H7N2S0, F0H8N2S0) exhibited significant diagnostic accuracy in both breast cancer cells and tissues, suggesting their potential role in biomarkers. [PMID:30889355]",
            "loinc_code": "",
            "tissue": {
                "name": "tissue",
                "namespace": "UBERON",
                "id": "0000479",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000479"
            },
            "disease": {
                "disease_id": "DOID:1612",
                "recommended_name": {
                    "id": "DOID:1612",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1612",
                    "name": "breast cancer",
                    "description": "A thoracic cancer that originates in the mammary gland."
                },
                "synonyms": [
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "breast tumor",
                        "description": ""
                    },
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "malignant neoplasm of breast",
                        "description": ""
                    },
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "malignant tumor of the breast",
                        "description": ""
                    },
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "mammary cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "mammary tumor",
                        "description": ""
                    },
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "primary breast cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "hereditary breast carcinoma",
                        "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, lobular, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, protection against, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "familial breast cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "familial breast carcinoma",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "familial cancer of breast",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "familial cancer of the breast",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "hereditary breast cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "hereditary breast carcinoma",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, familial",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, familial Male",
                        "description": ""
                    },
                    {
                        "id": "MIM:114480",
                        "resource": "MIM",
                        "url": "https://www.omim.org/entry/114480",
                        "name": "Breast cancer",
                        "description": "Breast cancer"
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000737",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000737"
                },
                {
                    "id": "30889355",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30889355"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Comprehensive N-Glycome Profiling of Cells and Tissues for Breast Cancer Diagnosis.",
            "journal": "Journal of proteome research",
            "authors": "Li Q, Li G, Zhou Y, Zhang X, Sun M, Jiang H, Yu G",
            "date": "2019",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30889355",
                    "url": "https://glygen.org/publication/PubMed/30889355"
                }
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                }
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            "id": "30889355",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/30889355"
        }
    ],
    "biomarker_id": "A0497",
    "aclist": [
        "G80966KZ"
    ],
    "crossref": [],
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