{
    "assessed_biomarker_entity": "Biantennary bisected core fucosylated N-glycan (A2G1(6)FB)",
    "assessed_entity_type": "glycan",
    "components": {
        "protein": [],
        "glycan": [
            {
                "accession": "G85767HW",
                "evidence": [
                    {
                        "id": "GLY_000737",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000737"
                    },
                    {
                        "id": "33255418",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/33255418"
                    }
                ]
            }
        ]
    },
    "instances": [
        {
            "best_biomarker_type": "diagnostic",
            "status": "increased (A2G1(6)FB) level",
            "notes": "",
            "literature_evidence": "The level of serum N-glycan A2G1(6)FB, a biantennary N-glycan containing core fucose and bisecting GlcNAc residues, was significantly higher in hepatitis C virus (HCV)-infected cirrhotic patients with HCC than in those without HCC. In addition, A2G1(6)FB was detectable in HCV-infected patients with early-stage HCC. In conclusion, the N-glycan A2G1(6)FB may be a potential biomarker to detect early HCC development in HCV-infected patients. [PMID:33255418]",
            "loinc_code": "",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:3571",
                "recommended_name": {
                    "id": "DOID:3571",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3571",
                    "name": "liver cancer",
                    "description": "A hepatobiliary system cancer that is located_in the liver."
                },
                "synonyms": [
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "Ca liver - primary",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "Resectable malignant neoplasm of Liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "hepatic cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "hepatic neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant hepato-biliary neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant neoplasm of liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant neoplasm of liver, primary",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant tumor of liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "neoplasm of liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "non-resectable primary hepatic malignant neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "primary liver cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "primary malignant neoplasm of liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "resectable malignant neoplasm of the liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant neoplasm of liver, not specified as primary or secondary",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000737",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000737"
                },
                {
                    "id": "33255418",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/33255418"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "A Potential Serum N-glycan Biomarker for Hepatitis C Virus-Related Early-Stage Hepatocellular Carcinoma with Liver Cirrhosis.",
            "journal": "International journal of molecular sciences",
            "authors": "Higashi M, Yoshimura T, Usui N, Kano Y, Deguchi A, Tanabe K, Uchimura Y, Kuriyama S, Suzuki Y, Masaki T, Ikenaka K",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33255418",
                    "url": "https://glygen.org/publication/PubMed/33255418"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000737",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000737"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000737",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000737"
        },
        {
            "id": "33255418",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/33255418"
        }
    ],
    "biomarker_id": "A0491",
    "aclist": [
        "G85767HW"
    ],
    "crossref": [],
    "section_stats": [
        {
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        {
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}