{
    "assessed_biomarker_entity": "Disialylated triantennary N-glycan",
    "assessed_entity_type": "glycan",
    "components": {
        "protein": [],
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            {
                "accession": "G46440UD",
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                        "id": "GLY_000737",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000737"
                    },
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                    }
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            "best_biomarker_type": "diagnostic",
            "status": "decreased disialylated triantennary N-glycan level",
            "notes": "",
            "literature_evidence": "Two statistical procedures implicated several sialylated and fucosylated N-glycan structures as highly probable biomarkers. Quantitative changes according to a cancer stage resulted when we categorized the glycans according to molecular size, number of oligomer branches, and abundance of sugar residues. Increases in sialylation and fucosylation of glycan structures appeared to be indicative of cancer progression. Different statistical evaluations confirmed independently that changes in the relative intensities of 8 N-glycans are characteristic of breast cancer (P < 0.001), whereas other glycan structures might contribute additionally to distinctions in the statistically recognizable patterns (different stages). [PMID:18487288]",
            "loinc_code": "",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:1612",
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                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1612",
                    "name": "breast cancer",
                    "description": "A thoracic cancer that originates in the mammary gland."
                },
                "synonyms": [
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                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "breast tumor",
                        "description": ""
                    },
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "malignant neoplasm of breast",
                        "description": ""
                    },
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "malignant tumor of the breast",
                        "description": ""
                    },
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "mammary cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "mammary tumor",
                        "description": ""
                    },
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "primary breast cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "hereditary breast carcinoma",
                        "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
                        "description": ""
                    },
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                        "id": "MONDO:0016419",
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                        "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, lobular, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
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                        "name": "breast cancer, protection against, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "familial breast cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "familial breast carcinoma",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "familial cancer of breast",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
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                        "name": "familial cancer of the breast",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "hereditary breast cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "hereditary breast carcinoma",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, familial",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, familial Male",
                        "description": ""
                    },
                    {
                        "id": "MIM:114480",
                        "resource": "MIM",
                        "url": "https://www.omim.org/entry/114480",
                        "name": "Breast cancer",
                        "description": "Breast cancer"
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000737",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000737"
                },
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                    "id": "18487288",
                    "database": "PubMed",
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                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Breast cancer diagnosis and prognosis through quantitative measurements of serum glycan profiles.",
            "journal": "Clinical chemistry",
            "authors": "Kyselova Z, Mechref Y, Kang P, Goetz JA, Dobrolecki LE, Sledge GW, Schnaper L, Hickey RJ, Malkas LH, Novotny MV",
            "date": "2008",
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                {
                    "type": "PubMed",
                    "id": "18487288",
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                }
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    "biomarker_id": "A0489",
    "aclist": [
        "G46440UD"
    ],
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