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"accession": "O43741-1", "name": "5'-AMP-activated protein kinase subunit beta-2", "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "30532555", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30532555" } ] }, { "accession": "Q8TEA8-1", "name": "D-aminoacyl-tRNA deacylase 1", "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "30532555", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30532555" } ] }, { "accession": "O75955-1", "name": "Flotillin-1", "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "30532555", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30532555" } ] }, { "accession": "Q9Y3B8-1", "name": "Oligoribonuclease, mitochondrial", "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "30532555", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30532555" } ] } ], "glycan": [] }, "instances": [ { "best_biomarker_type": "diagnostic", "status": "measured 48 gene expression level", "notes": "PCNP|SNRD13|CRELD1|SLC38A1|TPM2|TBL1X|HSD17B3|IFITM3|MS4A1|TEX9|PPDPF|PPP1R12C|AC004053.1|NUDT4|LAMB2|KLHDC8B|MEF2C-AS1|COL6A3|MYO5A|SMPD1|ZNF326|ZNF346|GLRX3|LGALS3BP|MYL9|ZNF706|CPED1|WDR11-AS1|SAMD14|CRYM|NRGN|PDHB|ROGDI|WASF1|AC090615.1|HERC2|ZFAND3|CKAP2|ARL2|RSRC1|HPSE|MLH3|CTSW|PRKAB2|DTD1|FLOT1|AL355073.1|REXO2|UPKB:Q8WW12|UPKB:Q96HD1|UPKB:Q9H2H9|UPKB:P07951|UPKB:O60907|UPKB:P37058|UPKB:Q01628|UPKB:P11836|UPKB:Q8N6V9|UPKB:Q9H3Y8|UPKB:Q9BZL4|UPKB:Q9NZJ9|UPKB:P55268|UPKB:Q8IXV7|UPKB:P12111|UPKB:Q9Y4I1|UPKB:P17405|UPKB:Q5BKZ1|UPKB:Q9UL40|UPKB:O76003|UPKB:Q08380|UPKB:P24844|UPKB:Q9Y5V0|UPKB:A4D0V7|UPKB:Q8IZD0|UPKB:Q14894|UPKB:Q92686|UPKB:P11177|UPKB:Q9GZN7|UPKB:Q92558|UPKB:O95714|UPKB:Q9H8U3|UPKB:Q8WWK9|UPKB:P36404|UPKB:Q96IZ7|UPKB:Q9Y251|UPKB:Q9UHC1|UPKB:P56202|UPKB:O43741|UPKB:Q8TEA8|UPKB:O75955|UPKB:Q9Y3B8|A0266|A0263|A0265|A0267|A0205|A0264", "literature_evidence": "48 biomarker genes accurately predicted NSCLC with leave-one-out cross-validation (LOOCV) sensitivity, specificity, accuracy, and Matthews correlation coefficients of 0.925, 0.827, 0.889, and 0.760, respectively. Network analysis of the 48 genes revealed that the WASF1 actin cytoskeleton module, PRKAB2 kinase module, RSRC1 ribosomal protein module, PDHB carbohydrate-metabolism module, and three intermodule hubs (TPM2, MYL9, and PPP1R12C) may play important roles in NSCLC tumorigenesis and progression. The 48-gene TEP liquid-biopsy biomarkers will facilitate early screening of NSCLC and prolong the survival of cancer patients. [PMID:30532555]", "loinc_code": "", "tissue": { "name": "blood", "namespace": "UBERON", "id": "0000178", "url": "http://purl.obolibrary.org/obo/UBERON_0000178" }, "disease": { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": 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}, { "id": "30532555", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30532555" } ] } ], "publication": [ { "title": "Identification of tumor-educated platelet biomarkers of non-small-cell lung cancer.", "journal": "OncoTargets and therapy", "authors": "Sheng M, Dong Z, Xie Y", "date": "2018", "reference": [ { "type": "PubMed", "id": "30532555", "url": "https://glygen.org/publication/PubMed/30532555" } ], "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" } ] } ], "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "30532555", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30532555" } ], "biomarker_id": "A0478", "aclist": [ "Q9GZN7-1", "O76003-1", "Q14894-1", "P11177-1", "P36404-1", "Q9Y251-1", "O60907-1", "Q9H8U3-1", "P11836-1", "Q01628-1", "Q9H2H9-1", "Q9UHC1-1", "P56202-1", "P12111-1", "Q9Y5V0-1", "P17405-1", "O75955-1", 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