{
    "assessed_biomarker_entity": "Uterine cancer increased plasma CD44, EPCAM, TGM2 panel",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "P16422-1",
                "name": "Epithelial cell adhesion molecule",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "31035965",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/31035965"
                    }
                ]
            },
            {
                "accession": "P16070-1",
                "name": "CD44 antigen",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "31035965",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/31035965"
                    }
                ]
            },
            {
                "accession": "P21980-1",
                "name": "Protein-glutamine gamma-glutamyltransferase 2",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "31035965",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/31035965"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "diagnostic",
            "status": "increased CD44, EPCAM, TGM2 level",
            "notes": "UPKB:P16422|UPKB:P16070|UPKB:P21980|CD44 antigen/Indian blood group|MTHU022199|Epithelial cell adhesion molecule|EPCAM|Protein-glutamine gamma-glutamyltransferase 2|Transglutaminase 2|TGM2",
            "literature_evidence": "Significantly increased concentration in EC as compared to healthy controls were found in case of CD44 (p < 0.001), EpCAM (p = 0.033) and TGM2 (p < 0.001). EpCAM and mesothelin concentrations differed based on FIGO stages. Regression analysis revealed marker panels with high accuracy in detection of EC (Endometrial cancer). The highest AUC 0.937 was attributed to the 3-marker panel of CD44/TGM2/EpCAM (84% sensitivity, 100% specificity), FIGO IA samples were discriminated from more advanced stages of EC with the mesothelin/grade 1 model featuring AUC of 0.911 (95.24% sensitivity, 78.26% specificity). Novel plasma biomarkers presenting good accuracy in diagnosing EC were found with TGM2 reported for the first time as plasma marker. It was also revealed that endometriosis may share similarities in the pattern of markers alterations characteristic for EC. [PMID:31035965]",
            "loinc_code": "LP234195-8",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:363",
                "recommended_name": {
                    "id": "DOID:363",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:363",
                    "name": "uterine cancer",
                    "description": "A female reproductive organ cancer that is located_in the uterus."
                },
                "synonyms": [
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "CA - cancer of uterus",
                        "description": ""
                    },
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "Tumour of uterus",
                        "description": ""
                    },
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "malignant neoplasm of uterus",
                        "description": ""
                    },
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "malignant uterine tumor",
                        "description": ""
                    },
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "neoplasm of uterus",
                        "description": ""
                    },
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "uterine tumor",
                        "description": ""
                    },
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "uterus neoplasm",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "31035965",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31035965"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "CD44, TGM2 and EpCAM as novel plasma markers in endometrial cancer diagnosis.",
            "journal": "BMC cancer",
            "authors": "Torres A, Pac-Sosinska M, Wiktor K, Paszkowski T, Maciejewski R, Torres K",
            "date": "2019",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31035965",
                    "url": "https://glygen.org/publication/PubMed/31035965"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "31035965",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/31035965"
        }
    ],
    "biomarker_id": "A0476",
    "aclist": [
        "P21980-1",
        "P16070-1",
        "P16422-1"
    ],
    "crossref": [],
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