{
    "assessed_biomarker_entity": "Liver cancer GOLM1, FC-KIN, FC-A1AT panel",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "P01042-1",
                "name": "Kininogen-1",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "19454616",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/19454616"
                    }
                ]
            },
            {
                "accession": "P02771-1",
                "name": "Alpha-fetoprotein",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "19454616",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/19454616"
                    }
                ]
            },
            {
                "accession": "Q8NBJ4-1",
                "name": "Golgi membrane protein 1",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "19454616",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/19454616"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "diagnostic",
            "status": "increased GOLM1, FC-KIN, FC-A1AT level",
            "notes": "EDRN panel biomarker|A0224|Golgi membrane protein 1|GOLM1|A0225|Fucosylated kininogen|FC-KIN|Fucosylated alpha-1-antitrypsin|A1AT|UPKB:Q8NBJ4|GP73|A0225|UPKB:P01042|UPKB:P01009",
            "literature_evidence": "The levels of fucosylated kininogen (Fc-Kin) and fucosylated \u03b1-1-antitrypsin were significantly higher in patients with HCC compared with those with cirrhosis (P < 0.0001). Greatest performance was achieved through the combination of Fc-Kin, \u03b1-fetoprotein, and GP73. These markers when used in combination with GP73 had an overall performance that was better than AFP alone. GP73 had a mean increase of 2.4-fold in patients with cirrhosis, 8.4-fold in patients with stage I or II HCC, and 8.1-fold in patients with stage III or IV HCC. [PMID:19454616]",
            "loinc_code": "",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:3571",
                "recommended_name": {
                    "id": "DOID:3571",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3571",
                    "name": "liver cancer",
                    "description": "A hepatobiliary system cancer that is located_in the liver."
                },
                "synonyms": [
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "Ca liver - primary",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "Resectable malignant neoplasm of Liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "hepatic cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "hepatic neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant hepato-biliary neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant neoplasm of liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant neoplasm of liver, primary",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant tumor of liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "neoplasm of liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "non-resectable primary hepatic malignant neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "primary liver cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "primary malignant neoplasm of liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "resectable malignant neoplasm of the liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant neoplasm of liver, not specified as primary or secondary",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "19454616",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/19454616"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Novel fucosylated biomarkers for the early detection of hepatocellular carcinoma.",
            "journal": "Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology",
            "authors": "Wang Mengjun, Long Ronald E, Comunale Mary Ann, Junaidi Omer, Marrero Jorge, Di Bisceglie Adrian M, Block Timothy M, Mehta Anand S",
            "date": "2009-06",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19454616",
                    "url": "https://glygen.org/publication/PubMed/19454616"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "19454616",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/19454616"
        }
    ],
    "biomarker_id": "A0470",
    "aclist": [
        "P01042-1",
        "Q8NBJ4-1",
        "P02771-1"
    ],
    "crossref": [],
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}