{
    "assessed_biomarker_entity": "Pancreatic cancer ten-microRNA expression index II panel",
    "assessed_entity_type": "RNA",
    "components": {
        "protein": [
            {
                "accession": "Q6P1J9-1",
                "name": "Parafibromin",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "24449318",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/24449318"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "diagnostic",
            "status": "measured 10 microRNAs level",
            "notes": "miRNA-26b|MIR-26b|miRNA-34a|MIR-34a|miRNA-122|MIR-122|miRNA-126*|MIR-126*|miRNA-145|MIR-145|miRNA-150|MIR-150|miRNA-223|MIR-223|miRNA-505|MIR-505|miRNA-636|MIR-636|miRNA-885.5p|MIR-885.5p",
            "literature_evidence": "The discovery cohort demonstrated that 38 microRNAs in whole blood were significantly dysregulated in patients with pancreatic cancer compared with controls. 2 diagnostic panels were constructed comprising 4 microRNAs in index I (miR-145, miR-150, miR-223, miR-636) and 10 in index II (miR-26b, miR-34a, miR-122, miR-126*, miR-145, miR-150, miR-223, miR-505, miR-636, miR-885.5p). [PMID:24449318]",
            "loinc_code": "",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:1793",
                "recommended_name": {
                    "id": "DOID:1793",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1793",
                    "name": "pancreatic cancer",
                    "description": "An endocrine gland cancer located_in the pancreas."
                },
                "synonyms": [
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "Ca body of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "Ca head of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "Ca tail of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "malignant neoplasm of body of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "malignant neoplasm of head of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "malignant neoplasm of tail of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "pancreas neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "pancreatic neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "pancreatic tumor",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "24449318",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/24449318"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "MicroRNA biomarkers in whole blood for detection of pancreatic cancer.",
            "journal": "JAMA",
            "authors": "Schultz Nicolai A, Dehlendorff Christian, Jensen Benny V, Bjerregaard Jon K, Nielsen Kaspar R, Bojesen Stig E, Calatayud Dan, Nielsen Svend E, Yilmaz Mette, Holl\u00e4nder Niels Henrik, Andersen Klaus K, Johansen Julia S",
            "date": "2014",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "24449318",
                    "url": "https://glygen.org/publication/PubMed/24449318"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "24449318",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/24449318"
        }
    ],
    "biomarker_id": "A0458",
    "aclist": [
        "Q6P1J9-1"
    ],
    "crossref": [],
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