{ "assessed_biomarker_entity": "Earlier stage ovarian cancer IL6, WFDC2, MUC16, CDH1 panel", "assessed_entity_type": "protein", "components": { "protein": [ { "accession": "P05231-1", "name": "Interleukin-6", "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "29572027", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29572027" } ] }, { "accession": "Q14508-1", "name": "WAP four-disulfide core domain protein 2", "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "29572027", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29572027" } ] }, { "accession": "Q8WXI7-1", "name": "Mucin-16", "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "29572027", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29572027" } ] }, { "accession": "P12830-1", "name": "Cadherin-1", "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "29572027", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29572027" } ] } ], "glycan": [] }, "instances": [ { "best_biomarker_type": "diagnostic", "status": "increased CA125, HE4, E-CAD, IL-6 level", "notes": "EDRN panel biomarker|A0032|UPKB:Q14508|A0035|UPKB:Q8WXI7|A0232|UPKB:P12830|A0001|UPKB:P05231|WFDC2|WAP four-disulfide core domain protein 2|MUC16|Mucin-16|CDH1|E-cadherin|IL6|Interleukin-6", "literature_evidence": "The four-marker panel, CA125, HE4, E-CAD, and IL-6, shows potential in detecting serous ovarian cancer at earlier stages. The 4-marker panel had the highest average sensitivity under the region of its ROC curve corresponding to specificity ranging from 100% down to ~95%. 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Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, somatic", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, epithelial", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "primary ovarian cancer", "description": "" }, { "id": "MIM:167000", "resource": "MIM", "url": "https://www.omim.org/entry/167000", "name": "Ovarian cancer", "description": "Ovarian cancer" } ] }, "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "29572027", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29572027" } ] } ], "publication": [ { "title": "A novel multiple biomarker panel for the early detection of high-grade serous ovarian carcinoma.", "journal": "Gynecologic oncology", "authors": "Han Chanhee, Bellone Stefania, Siegel Eric R, Altwerger Gary, Menderes Gulden, Bonazzoli Elena, Egawa-Takata Tomomi, Pettinella Francesca, Bianchi Anna, Riccio Francesco, Zammataro Luca, Yadav Ghanshyam, Marto Jarrod A, Penet Marie-France, Levine Douglas A, Drapkin Ronny, Patel Abhijit, Litkouhi Babak, Ratner Elena, Silasi Dan-Arin, Huang Gloria S, Azodi Masoud, Schwartz Peter E, Santin Alessandro D", "date": "2018-06", "reference": [ { "type": "PubMed", "id": "29572027", "url": "https://glygen.org/publication/PubMed/29572027" } ], "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" } ] } ], "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "29572027", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29572027" } ], "biomarker_id": "A0456", "aclist": [ "P12830-1", "Q8WXI7-1", "P05231-1", "Q14508-1" ], "crossref": [], "section_stats": [ { "table_id": "instances", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "best_biomarker_type", "status", "notes", "literature_evidence", "loinc_code", "tissue.name", "tissue.namespace", "tissue.id", "tissue.url", "disease.disease_id" ] }, { "table_id": "components", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "authors", "date" ] } ] }