{
    "assessed_biomarker_entity": "Squamous cell carcinoma antigen-Immunoglobulin M complex (SCCA-IgM IC)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "Q6P1J9-1",
                "name": "Parafibromin",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
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                        "url": "https://glygen.org/publication/PubMed/15887222"
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        {
            "best_biomarker_type": "diagnostic",
            "status": "increased SCCA-IgM IC level",
            "notes": "Measured in serum (UN:0001977) as well",
            "literature_evidence": "In the current study, we have demonstrated that SCCA variants, which are overexpressed remarkably in liver tumor tissues, are detectable in serum from patients with HCC coupled to IgMs to form circulating Ics. [PMID:15887222]",
            "loinc_code": "",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:3571",
                "recommended_name": {
                    "id": "DOID:3571",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3571",
                    "name": "liver cancer",
                    "description": "A hepatobiliary system cancer that is located_in the liver."
                },
                "synonyms": [
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "Ca liver - primary",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "Resectable malignant neoplasm of Liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "hepatic cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "hepatic neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant hepato-biliary neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant neoplasm of liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant neoplasm of liver, primary",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant tumor of liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "neoplasm of liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "non-resectable primary hepatic malignant neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "primary liver cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "primary malignant neoplasm of liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "resectable malignant neoplasm of the liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant neoplasm of liver, not specified as primary or secondary",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "15887222",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/15887222"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Squamous cell carcinoma antigen-immunoglobulin M complexes as novel biomarkers for hepatocellular carcinoma.",
            "journal": "Cancer",
            "authors": "Beneduce Luca, Castaldi Francesco, Marino Maria, Quarta Santina, Ruvoletto Mariagrazia, Benvegn\u00f9 Luisa, Calabrese Fiorella, Gatta Angelo, Pontisso Patrizia, Fassina Giorgio",
            "date": "2005-06-15",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15887222",
                    "url": "https://glygen.org/publication/PubMed/15887222"
                }
            ],
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                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
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        {
            "id": "15887222",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/15887222"
        }
    ],
    "biomarker_id": "A0447",
    "aclist": [
        "Q6P1J9-1"
    ],
    "crossref": [],
    "section_stats": [
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}