{
    "assessed_biomarker_entity": "Interleukin-1 beta protein (IL1B)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "P01584-1",
                "name": "Interleukin-1 beta",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "32511562",
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                        "url": "https://glygen.org/publication/PubMed/32511562"
                    },
                    {
                        "id": "31986264",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/31986264"
                    },
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                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/21109482"
                    },
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                        "database": "PubMed",
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                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "increased IL1B level",
            "notes": "Measured in serum (UN:0001977) as well.",
            "literature_evidence": "COVID-19 is associated with high levels of IL-6, TNF-a, IL-1b, and CXCL8/IL-8. IL-6 was one of the most robust prognostic markers of survival. It remained independently associated with severity and predictive of outcome. Furthermore, elevated TNF-a, known to contribute to organ damage, was also a strong predictor of poor outcome. [PMID:32511562]",
            "loinc_code": "13629-1",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:0080600",
                "recommended_name": {
                    "id": "DOID:0080600",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080600",
                    "name": "COVID-19",
                    "description": "A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2."
                },
                "synonyms": [
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019 Novel Coronavirus (2019-nCoV)",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019-nCoV infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan coronavirus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan seafood market pneumonia virus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "COVID19",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "SARS-CoV-2 infection",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "32511562",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32511562"
                },
                {
                    "id": "31986264",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31986264"
                }
            ]
        },
        {
            "best_biomarker_type": "diagnostic",
            "status": "increased IL1B level",
            "notes": "oral squamous cell carcinoma (DOID:0050866)",
            "literature_evidence": "IL1B protein and IL8 protein as well as S100P mRNA were increased the most between all OSCC patients and controls with a fold change of 3.96, 3.09, and 3.24 respectively. Combined markers proved to be the strongest discriminator of OSCC with an AUC of 0.86 for all cancer patients (IL1B protein + SAT1 mRNA + DUSP1 mRNA), 0.85 for T1-T2 (IL1B mRNA + SAT1 mRNA + DUSP1 mRNA), and 0.88 for T3-T4 (IL1B protein + DUSP1 mRNA) (Figure 1\u00a0and\u00a0Table 3). The sensitivity/specificity for these groups were 0.89/0.78, 0.67/0.96, and 0.82/0.84 respectively. [PMID:21109482]",
            "loinc_code": "13629-1",
            "tissue": {
                "name": "saliva",
                "namespace": "UBERON",
                "id": "0001836",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001836"
            },
            "disease": {
                "disease_id": "DOID:11934",
                "recommended_name": {
                    "id": "DOID:11934",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:11934",
                    "name": "head and neck cancer",
                    "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
                },
                "synonyms": [
                    {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "head and neck neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "head and neck tumours",
                        "description": ""
                    },
                    {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "head/neck neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "tumor of head and neck",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "21109482",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/21109482"
                }
            ]
        },
        {
            "best_biomarker_type": "monitoring",
            "status": "decreased IL1B level",
            "notes": "",
            "literature_evidence": "Changes in expression of IL1B, early growth response gene 3, and prostaglandin-endoperoxide synthase 2 resolved within 4 months of insulin therapy and were also observed in T2D, suggesting that they resulted from hyperglycemia. With use of a knowledge base, 81 of 282 genes could be placed within a network of interrelated genes with predicted functions including apoptosis and cell proliferation. IL1B and the MYC oncogene were the most highly connected genes in the network. IL1B was highly overexpressed in both T1D and T2D, whereas MYC was dysregulated only in T1D. [PMID:17595242]",
            "loinc_code": "13629-1",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:9351",
                "recommended_name": {
                    "id": "DOID:9351",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9351",
                    "name": "diabetes mellitus",
                    "description": "A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both."
                },
                "synonyms": [
                    {
                        "id": "DOID:9351",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:9351",
                        "name": "diabetes",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "17595242",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/17595242"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "An inflammatory cytokine signature helps predict COVID-19 severity and death.",
            "journal": "medRxiv : the preprint server for health sciences",
            "authors": "Del Valle DM, Kim-Schulze S, Hsin-Hui H, Beckmann ND, Nirenberg S, Wang B, Lavin Y, Swartz T, Madduri D, Stock A, Marron T, Xie H, Patel MK, van Oekelen O, Rahman A, Kovatch P, Aberg J, Schadt E, Jagannath S, Mazumdar M, Charney A, Firpo-Betancourt A, Mendu DR, Jhang J, Reich D, Sigel K, Cordon-Cardo C, Feldmann M, Parekh S, Merad M, Gnjatic S",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32511562",
                    "url": "https://glygen.org/publication/PubMed/32511562"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        },
        {
            "title": "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.",
            "journal": "Lancet (London, England)",
            "authors": "Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B",
            "date": "2020",
            "reference": [
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                    "type": "PubMed",
                    "id": "31986264",
                    "url": "https://glygen.org/publication/PubMed/31986264"
                }
            ],
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                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        },
        {
            "title": "Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population.",
            "journal": "Oral oncology",
            "authors": "Brinkmann O, Kastratovic DA, Dimitrijevic MV, Konstantinovic VS, Jelovac DB, Antic J, Nesic VS, Markovic SZ, Martinovic ZR, Akin D, Spielmann N, Zhou H, Wong DT",
            "date": "2011",
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                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        },
        {
            "title": "Gene expression in peripheral blood mononuclear cells from children with diabetes.",
            "journal": "The Journal of clinical endocrinology and metabolism",
            "authors": "Kaizer EC, Glaser CL, Chaussabel D, Banchereau J, Pascual V, White PC",
            "date": "2007",
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    "biomarker_id": "A0445",
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    ],
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