{
    "assessed_biomarker_entity": "Alpha-ketoglutarate-dependent dioxygenase (FTO)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "Q9C0B1-1",
                "name": "Alpha-ketoglutarate-dependent dioxygenase FTO",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "31985880",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/31985880"
                    },
                    {
                        "id": "34683137",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/34683137"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "decreased FTO level",
            "notes": "Fat mass and obesity-associated protein (FTO)",
            "literature_evidence": "ALKBH5 was significantly reduced in RCC compared to normal tissue (P < 0.001), low expression levels of ALKBH5 and FTO were correlated with a shorter overall survival (OS: ALKBH5 log-rank P = 0.007; FTO log-rank P = 0.033) and cancer-specific survival (CSS: ALKBH5 log-rank P = 0.018; FTO log-rank P = 0.029 [PMID: 31985880]. Univariate analysis showed that higher FTO expression was associated with better overall and progression free survival in both ccRCC and pRCC patients. No associations were disclosed concerning ALKBH5 expressions levels. [PMID:34683137]",
            "loinc_code": "",
            "tissue": {
                "name": "kidney",
                "namespace": "UBERON",
                "id": "0002113",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002113"
            },
            "disease": {
                "disease_id": "DOID:263",
                "recommended_name": {
                    "id": "DOID:263",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:263",
                    "name": "kidney cancer",
                    "description": "A urinary system cancer that is located_in the kidney."
                },
                "synonyms": [
                    {
                        "id": "DOID:263",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:263",
                        "name": "malignant neoplasm of kidney except pelvis",
                        "description": ""
                    },
                    {
                        "id": "DOID:263",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:263",
                        "name": "malignant tumour of kidney",
                        "description": ""
                    },
                    {
                        "id": "DOID:263",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:263",
                        "name": "renal cancer",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "31985880",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31985880"
                },
                {
                    "id": "34683137",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/34683137"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "The N6 -methyladenosine (m6 A) erasers alkylation repair homologue 5 (ALKBH5) and fat mass and obesity-associated protein (FTO) are prognostic biomarkers in patients with clear cell renal carcinoma.",
            "journal": "BJU international",
            "authors": "Strick Alexander, von Hagen Felix, Gundert Larissa, Kl\u00fcmper Niklas, Tolkach Yuri, Schmidt Doris, Kristiansen Glen, Toma Marieta, Ritter Manuel, Ellinger J\u00f6rg",
            "date": "2020-04",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31985880",
                    "url": "https://glygen.org/publication/PubMed/31985880"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        },
        {
            "title": "Deregulation of N6-Methyladenosine RNA Modification and Its Erasers FTO/ALKBH5 among the Main Renal Cell Tumor Subtypes.",
            "journal": "Journal of personalized medicine",
            "authors": "Guimar\u00e3es-Teixeira Catarina, Barros-Silva Daniela, Lobo Jo\u00e3o, Soares-Fernandes Diana, Const\u00e2ncio Vera, Leite-Silva Pedro, Silva-Santos Rui, Braga Isaac, Henrique Rui, Miranda-Gon\u00e7alves Vera, Jer\u00f3nimo Carmen",
            "date": "2021-09-30",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "34683137",
                    "url": "https://glygen.org/publication/PubMed/34683137"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "31985880",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/31985880"
        },
        {
            "id": "34683137",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/34683137"
        }
    ],
    "biomarker_id": "A0437",
    "aclist": [
        "Q9C0B1-1"
    ],
    "crossref": [],
    "section_stats": [
        {
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}