{
    "assessed_biomarker_entity": "Lewis x fucosylated monogalactosylated triantennary N-glycan (A3FG1)",
    "assessed_entity_type": "glycan",
    "components": {
        "protein": [],
        "glycan": [
            {
                "accession": "G36521AS",
                "evidence": [
                    {
                        "id": "GLY_000737",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000737"
                    },
                    {
                        "id": "18818422",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/18818422"
                    }
                ]
            }
        ]
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "increased A3FG1 level",
            "notes": "",
            "literature_evidence": "Following digestion with sialidase and beta-galactosidase, the alpha1,3-fucosylated trisialylated triantennary structure (A3FG3S3, GU 10.75) digested to form the alpha1,3-fucosylated monogalactosylated triantennary structure (A3FG1). We observed a significant difference in the trends of both A3FG1 and CA 15-3 in all 10 patients. Interestingly, we found that A3FG1 increased in all the second samples, clearly consistent with breast cancer progression and/or metastasis. This preliminary result suggests that compared to the commonly measured CA 15-3 and CEA, the glycan marker A3FG1, quantified from whole serum of breast cancer patients, could be more reliable for detecting disease progression and metastasis. [PMID:18818422]",
            "loinc_code": "",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:1612",
                "recommended_name": {
                    "id": "DOID:1612",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1612",
                    "name": "breast cancer",
                    "description": "A thoracic cancer that originates in the mammary gland."
                },
                "synonyms": [
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "breast tumor",
                        "description": ""
                    },
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "malignant neoplasm of breast",
                        "description": ""
                    },
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "malignant tumor of the breast",
                        "description": ""
                    },
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "mammary cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "mammary tumor",
                        "description": ""
                    },
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "primary breast cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "hereditary breast carcinoma",
                        "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, lobular, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, protection against, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "familial breast cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "familial breast carcinoma",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "familial cancer of breast",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "familial cancer of the breast",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "hereditary breast cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "hereditary breast carcinoma",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, familial",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, familial Male",
                        "description": ""
                    },
                    {
                        "id": "MIM:114480",
                        "resource": "MIM",
                        "url": "https://www.omim.org/entry/114480",
                        "name": "Breast cancer",
                        "description": "Breast cancer"
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000737",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000737"
                },
                {
                    "id": "18818422",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/18818422"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "A strategy to reveal potential glycan markers from serum glycoproteins associated with breast cancer progression.",
            "journal": "Glycobiology",
            "authors": "Abd Hamid UM, Royle L, Saldova R, Radcliffe CM, Harvey DJ, Storr SJ, Pardo M, Antrobus R, Chapman CJ, Zitzmann N, Robertson JF, Dwek RA, Rudd PM",
            "date": "2008",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18818422",
                    "url": "https://glygen.org/publication/PubMed/18818422"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000737",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000737"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000737",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000737"
        },
        {
            "id": "18818422",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/18818422"
        }
    ],
    "biomarker_id": "A0418",
    "aclist": [
        "G36521AS"
    ],
    "crossref": [],
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