{
    "assessed_biomarker_entity": "GDNF family receptor alpha-3 gene promoter methylation (GFRA3)",
    "assessed_entity_type": "gene",
    "components": {
        "protein": [
            {
                "accession": "O60609-1",
                "name": "GDNF family receptor alpha-3",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "26984265",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/26984265"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "increased methylation",
            "notes": "UPKB:O60609",
            "literature_evidence": "The different DNA methylation clusters of the tumors and normal tissue indicate that aberrant DNA methylation is a distinct feature of gastric cancer, although there is little difference in the overall, and low, methylation levels between the two tissue types. The GFRA3 promoter region showed marked hypermethylation in almost all tumors, and its correlation with survival and other clinicopathological parameters may have important prognostic significance. [PMID:26984265]",
            "loinc_code": "",
            "tissue": {
                "name": "stomach",
                "namespace": "UBERON",
                "id": "0000945",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000945"
            },
            "disease": {
                "disease_id": "DOID:10534",
                "recommended_name": {
                    "id": "DOID:10534",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10534",
                    "name": "stomach cancer",
                    "description": "A gastrointestinal system cancer that is located_in the stomach."
                },
                "synonyms": [
                    {
                        "id": "DOID:10534",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:10534",
                        "name": "gastric cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:10534",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:10534",
                        "name": "gastric neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "gastric cancer",
                        "description": "A primary or metastatic malignant neoplasm involving the stomach."
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "gastric neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "Ca lesser curvature - stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "cancer of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "gastric cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "gastric cancer risk after h. pylori infection",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "gastric cancer, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant gastric neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant gastric tumor",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant neoplasm of lesser curve of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant neoplasm of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant neoplasm of the stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant stomach neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant tumor of body of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant tumor of greater curve of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant tumor of lesser curve of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant tumor of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant tumor of the stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "stomach cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "Ca body - stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "ca greater curvature of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant neoplasm of body of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "gastric cancer, intestinal",
                        "description": ""
                    },
                    {
                        "id": "MIM:613659",
                        "resource": "MIM",
                        "url": "https://www.omim.org/entry/613659",
                        "name": "Gastric cancer",
                        "description": "Gastric cancer"
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "26984265",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/26984265"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "GFRA3 promoter methylation may be associated with decreased postoperative survival in gastric cancer.",
            "journal": "BMC cancer",
            "authors": "Eftang LL, Klajic J, Kristensen VN, Tost J, Esbensen QY, Blom GP, Bukholm IR, Bukholm G",
            "date": "2016",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26984265",
                    "url": "https://glygen.org/publication/PubMed/26984265"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "26984265",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/26984265"
        }
    ],
    "biomarker_id": "A0386",
    "aclist": [
        "O60609-1"
    ],
    "crossref": [],
    "section_stats": [
        {
            "table_id": "instances",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "best_biomarker_type",
                "status",
                "notes",
                "literature_evidence",
                "loinc_code",
                "tissue.name",
                "tissue.namespace",
                "tissue.id",
                "tissue.url",
                "disease.disease_id"
            ]
        },
        {
            "table_id": "components",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}