{
    "assessed_biomarker_entity": "Glutathione peroxidase 1 (GPX1)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "P07203-1",
                "name": "Glutathione peroxidase 1",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
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                        "id": "31844035",
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                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "diagnostic",
            "status": "increased GPX1 level",
            "notes": "",
            "literature_evidence": "Bioinformatics analysis found that high expression of GPX1 was positively correlated with tumor stage, distant metastasis and lymphatic metastasis. ROC curve analysis found that high expression of GPX1 could effectively distinguish ccRCC from normal individuals. [PMID:31844035]",
            "loinc_code": "LP15611-4",
            "tissue": {
                "name": "kidney",
                "namespace": "UBERON",
                "id": "0002113",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002113"
            },
            "disease": {
                "disease_id": "DOID:263",
                "recommended_name": {
                    "id": "DOID:263",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:263",
                    "name": "kidney cancer",
                    "description": "A urinary system cancer that is located_in the kidney."
                },
                "synonyms": [
                    {
                        "id": "DOID:263",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:263",
                        "name": "malignant neoplasm of kidney except pelvis",
                        "description": ""
                    },
                    {
                        "id": "DOID:263",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:263",
                        "name": "malignant tumour of kidney",
                        "description": ""
                    },
                    {
                        "id": "DOID:263",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:263",
                        "name": "renal cancer",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "31844035",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31844035"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "GPX1, a biomarker for the diagnosis and prognosis of kidney cancer, promotes the progression of kidney cancer.",
            "journal": "Aging",
            "authors": "Cheng Y, Xu T, Li S, Ruan H",
            "date": "2019",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31844035",
                    "url": "https://glygen.org/publication/PubMed/31844035"
                }
            ],
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                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "31844035",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/31844035"
        }
    ],
    "biomarker_id": "A0382",
    "aclist": [
        "P07203-1"
    ],
    "crossref": [],
    "section_stats": [
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}