{
    "assessed_biomarker_entity": "Low-density lipoprotein receptor-related protein 1B gene mutation (LRP1B)",
    "assessed_entity_type": "gene",
    "components": {
        "protein": [
            {
                "accession": "Q9NZR2-1",
                "name": "Low-density lipoprotein receptor-related protein 1B",
                "evidence": [
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                        "url": "https://data.glygen.org/GLY_000625"
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    },
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            "best_biomarker_type": "prognostic",
            "status": "increased mutation",
            "notes": "Also a diagnostic biomarker|UPKB:Q9NZR2",
            "literature_evidence": "LRP1B is one of the top 10 genes with high gene mutation frequency in gastric cancer. The mutation status of LRP1B in gastric cancer patients was significantly correlated with age and TP53 and MUC16 mutation status. The result of ROC curve analysis revealed that the mutation status of LRP1B could be considered as an indicator of the degree of TMB in patients with gastric cancer. [PMID:34603481]",
            "loinc_code": "",
            "tissue": {
                "name": "stomach",
                "namespace": "UBERON",
                "id": "0000945",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000945"
            },
            "disease": {
                "disease_id": "DOID:10534",
                "recommended_name": {
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                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10534",
                    "name": "stomach cancer",
                    "description": "A gastrointestinal system cancer that is located_in the stomach."
                },
                "synonyms": [
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                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:10534",
                        "name": "gastric cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:10534",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:10534",
                        "name": "gastric neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "gastric cancer",
                        "description": "A primary or metastatic malignant neoplasm involving the stomach."
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "gastric neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "Ca lesser curvature - stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "cancer of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "gastric cancer",
                        "description": ""
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                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "gastric cancer risk after h. pylori infection",
                        "description": ""
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                        "resource": "MONDO",
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                        "name": "gastric cancer, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
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                        "name": "malignant gastric neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
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                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant gastric tumor",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant neoplasm of lesser curve of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant neoplasm of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
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                        "name": "malignant neoplasm of the stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
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                        "name": "malignant stomach neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant tumor of body of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant tumor of greater curve of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant tumor of lesser curve of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
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                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant tumor of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
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                        "name": "malignant tumor of the stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
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                    },
                    {
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                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
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                        "name": "ca greater curvature of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant neoplasm of body of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "gastric cancer, intestinal",
                        "description": ""
                    },
                    {
                        "id": "MIM:613659",
                        "resource": "MIM",
                        "url": "https://www.omim.org/entry/613659",
                        "name": "Gastric cancer",
                        "description": "Gastric cancer"
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "34603481",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/34603481"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Correlation between LRP1B Mutations and Tumor Mutation Burden in Gastric Cancer.",
            "journal": "Computational and mathematical methods in medicine",
            "authors": "Hu S, Zhao X, Qian F, Jin C, Hou K",
            "date": "2021",
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                {
                    "type": "PubMed",
                    "id": "34603481",
                    "url": "https://glygen.org/publication/PubMed/34603481"
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    ],
    "biomarker_id": "A0381",
    "aclist": [
        "Q9NZR2-1"
    ],
    "crossref": [],
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