{
    "assessed_biomarker_entity": "Protein arginine methyltransferase-1 (PRMT1)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "Q99873-1",
                "name": "Protein arginine N-methyltransferase 1",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "31655611",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/31655611"
                    },
                    {
                        "id": "33859753",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/33859753"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "decreased PRMT1 level",
            "notes": "",
            "literature_evidence": "Nuclear PRMT1 IHC expression was seen in all samples of the renal parenchyma used as a positive control. PRMT1 expression together with low-nuclear tumor grade and stage were significantly associated with better cancer-specific survival (p = 0.029). Patients who died of clear cell Renal Cell Carcinoma (ccRCC) showed homogenous loss of PRMT1 in 44.7%. [PMID:31655611] Taken together, our study revealed a PRMT1-dependent epigenetic mechanism in the control of clear cell renal cell carcinoma (ccRCC) tumor growth and drug resistance, indicating PRMT1 may serve as a promising target for therapeutic intervention in ccRCC patients. [PMID:33859753]",
            "loinc_code": "",
            "tissue": {
                "name": "kidney",
                "namespace": "UBERON",
                "id": "0002113",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002113"
            },
            "disease": {
                "disease_id": "DOID:263",
                "recommended_name": {
                    "id": "DOID:263",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:263",
                    "name": "kidney cancer",
                    "description": "A urinary system cancer that is located_in the kidney."
                },
                "synonyms": [
                    {
                        "id": "DOID:263",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:263",
                        "name": "malignant neoplasm of kidney except pelvis",
                        "description": ""
                    },
                    {
                        "id": "DOID:263",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:263",
                        "name": "malignant tumour of kidney",
                        "description": ""
                    },
                    {
                        "id": "DOID:263",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:263",
                        "name": "renal cancer",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "31655611",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31655611"
                },
                {
                    "id": "33859753",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/33859753"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance.",
            "journal": "Diagnostic pathology",
            "authors": "Filipovic J, Bosic M, Cirovic S, Zivotic M, Dunderovic D, Dordevic D, Zivkovic-Perisic S, Lipkovski A, Markovic-Lipkovski J",
            "date": "2019",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31655611",
                    "url": "https://glygen.org/publication/PubMed/31655611"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        },
        {
            "title": "PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.",
            "journal": "Theranostics",
            "authors": "Wang J, Wang C, Xu P, Li X, Lu Y, Jin D, Yin X, Jiang H, Huang J, Xiong H, Ye F, Jin J, Chen Y, Xie Y, Chen Z, Ding H, Zhang H, Liu R, Jiang H, Chen K, Yao Z, Luo C, Huang Y, Zhang Y, Zhang J",
            "date": "2021",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33859753",
                    "url": "https://glygen.org/publication/PubMed/33859753"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
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            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
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            "id": "31655611",
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        },
        {
            "id": "33859753",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/33859753"
        }
    ],
    "biomarker_id": "A0370",
    "aclist": [
        "Q99873-1"
    ],
    "crossref": [],
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