{
    "assessed_biomarker_entity": "Cyclin D2 (CCND2)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "P30279-1",
                "name": "G1/S-specific cyclin-D2",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "28643014",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/28643014"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "increased CCND2 level",
            "notes": "CCND2 expression",
            "literature_evidence": "The presence of nuclear CCND2 expression in >10% tumor cells, assessed in 62 of these patients who had informative cores, was significantly related to longer Overall Survival (OS) (p = 0.012; Fig. 2b). TGLN (p < 0.001), NAV2 (p < 0.001), and FABP3 (p = 0.005) were overexpressed in LMS compared to LG ESS, whereas nuclear CCND2 (p < 0.001) was overexpressed in LG-ESS. NAV2 expression was associated with shorter overall survival in patients with LMS (p = 0.037), whereas nuclear CCND2 expression in LG-ESS was significantly related to longer survival (p = 0.012) in univariate analysis. Nuclear CCND2 expression was an independent prognosticator in Cox multivariate analysis (p = 0.023). In conclusion, TGLN, FABP3, NAV2, and nuclear CCND2 aid in differentiating LG-ESS from LMS. NAV2 and CCND2 are novel candidate prognostic markers in LMS and LG-ESS, respectively. [PMID:28643014]",
            "loinc_code": "",
            "tissue": {
                "name": "uterus",
                "namespace": "UBERON",
                "id": "0000995",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000995"
            },
            "disease": {
                "disease_id": "DOID:363",
                "recommended_name": {
                    "id": "DOID:363",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:363",
                    "name": "uterine cancer",
                    "description": "A female reproductive organ cancer that is located_in the uterus."
                },
                "synonyms": [
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "CA - cancer of uterus",
                        "description": ""
                    },
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "Tumour of uterus",
                        "description": ""
                    },
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "malignant neoplasm of uterus",
                        "description": ""
                    },
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "malignant uterine tumor",
                        "description": ""
                    },
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "neoplasm of uterus",
                        "description": ""
                    },
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "uterine tumor",
                        "description": ""
                    },
                    {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "uterus neoplasm",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "28643014",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/28643014"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Neuron navigator-2 and cyclin D2 are new candidate prognostic markers in uterine sarcoma.",
            "journal": "Virchows Archiv : an international journal of pathology",
            "authors": "Davidson B, Hellesylt E, Holth A, Danielsen HE, Skeie-Jensen T, Katz B",
            "date": "2017",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "28643014",
                    "url": "https://glygen.org/publication/PubMed/28643014"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "28643014",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/28643014"
        }
    ],
    "biomarker_id": "A0355",
    "aclist": [
        "P30279-1"
    ],
    "crossref": [],
    "section_stats": [
        {
            "table_id": "instances",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "best_biomarker_type",
                "status",
                "notes",
                "literature_evidence",
                "loinc_code",
                "tissue.name",
                "tissue.namespace",
                "tissue.id",
                "tissue.url",
                "disease.disease_id"
            ]
        },
        {
            "table_id": "components",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}