{
    "assessed_biomarker_entity": "Extracellular matrix protein 1 (ECM1)",
    "assessed_entity_type": "gene",
    "components": {
        "protein": [
            {
                "accession": "Q16610-1",
                "name": "Extracellular matrix protein 1",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "16135921",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/16135921"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "diagnostic",
            "status": "increased EMC1 level",
            "notes": "Upregulation of EMC1",
            "literature_evidence": "By cDNA array analysis, ADAMTS8, ECM1, MMP8, PLAU, SELP, and TMPRSS4 were upregulated, and by quantitative PCR, ECM1, SELP, and TMPRSS4 mRNA expression was higher in malignant (n = 57) than in benign (n = 38) thyroid neoplasms. Combining both markers improved their diagnostic use (AUC 0.985; sensitivity, 91.7%; specificity, 89.8%; positive predictive value, 85.7%; negative predictive value, 82.8%). ECM1 and TMPRSS4 expression analysis improved the diagnostic accuracy of FNA biopsy in 35 of 38 indeterminate or suspicious results. [PMID:16135921]",
            "loinc_code": "",
            "tissue": {
                "name": "thyroid gland",
                "namespace": "UBERON",
                "id": "0002046",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002046"
            },
            "disease": {
                "disease_id": "DOID:1781",
                "recommended_name": {
                    "id": "DOID:1781",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1781",
                    "name": "thyroid gland cancer",
                    "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                },
                "synonyms": [
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "Thyroid gland neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "malignant neoplasm of thyroid gland",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "malignant tumour of thyroid gland",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "neoplasm of thyroid gland",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "thyroid neoplasm",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "16135921",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/16135921"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "ECM1 and TMPRSS4 are diagnostic markers of malignant thyroid neoplasms and improve the accuracy of fine needle aspiration biopsy.",
            "journal": "Annals of surgery",
            "authors": "Kebebew E, Peng M, Reiff E, Duh QY, Clark OH, McMillan A",
            "date": "2005",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16135921",
                    "url": "https://glygen.org/publication/PubMed/16135921"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "16135921",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/16135921"
        }
    ],
    "biomarker_id": "A0344",
    "aclist": [
        "Q16610-1"
    ],
    "crossref": [],
    "section_stats": [
        {
            "table_id": "instances",
            "table_stats": [
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            ],
            "sort_fields": [
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                "status",
                "notes",
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                "tissue.id",
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        {
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}