{
    "assessed_biomarker_entity": "Close homolog of L1 (CHL1)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "O00533-1",
                "name": "Neural cell adhesion molecule L1-like protein",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "30311656",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/30311656"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "increased CHL1 level",
            "notes": "Increased expression of CHL1",
            "literature_evidence": "CHL1 was found to have greater than 15-fold higher expression in fragments per kilobase million in HCC compared with benign Hurthle cell tumors. This was confirmed by qRT-PCR. Moreover, the immunoreactivity score of the CHL1 protein was significantly higher in HCC compared with benign H\u00fcrthle cell nodules. Moreover, the immunoreactivity score of the CHL1 protein was significantly higher in HCC compared with benign H\u00fcrthle cell nodules. CHL1 expression may represent a novel and useful prognostic biomarker to distinguish HCC from benign H\u00fcrthle cell disease. [PMID:30311656]",
            "loinc_code": "",
            "tissue": {
                "name": "thyroid gland",
                "namespace": "UBERON",
                "id": "0002046",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002046"
            },
            "disease": {
                "disease_id": "DOID:1781",
                "recommended_name": {
                    "id": "DOID:1781",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1781",
                    "name": "thyroid gland cancer",
                    "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                },
                "synonyms": [
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "Thyroid gland neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "malignant neoplasm of thyroid gland",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "malignant tumour of thyroid gland",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "neoplasm of thyroid gland",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "thyroid neoplasm",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "30311656",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30311656"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "CHL1 expression differentiates Hurthle cell carcinoma from benign Hurthle cell nodules.",
            "journal": "Journal of surgical oncology",
            "authors": "Li W, Xia S, Aronova A, Min IM, Verma A, Scognamiglio T, Gray KD, Ullmann TM, Liang H, Moore MD, Elemento O, Zarnegar R, Fahey TJ",
            "date": "2018",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30311656",
                    "url": "https://glygen.org/publication/PubMed/30311656"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "30311656",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/30311656"
        }
    ],
    "biomarker_id": "A0331",
    "aclist": [
        "O00533-1"
    ],
    "crossref": [],
    "section_stats": [
        {
            "table_id": "instances",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "best_biomarker_type",
                "status",
                "notes",
                "literature_evidence",
                "loinc_code",
                "tissue.name",
                "tissue.namespace",
                "tissue.id",
                "tissue.url",
                "disease.disease_id"
            ]
        },
        {
            "table_id": "components",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
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                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}