{ "assessed_biomarker_entity": "PIN2/TERF1 interacting telomerase inhibitor 1 (PINX1)", "assessed_entity_type": "protein", "components": { "protein": [ { "accession": "Q96BK5-1", "name": "PIN2/TERF1-interacting telomerase inhibitor 1", "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "30026037", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30026037" }, { "id": "26033551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26033551" }, { "id": "31254127", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31254127" } ] } ], "glycan": [] }, "instances": [ { "best_biomarker_type": "prognostic", "status": "increased PINX1 level", "notes": "Increased PINX1 expression", "literature_evidence": "Immunohistochemistry for PINX1 was performed using a tissue microarray of samples taken from the 160 patients with PTC. PINX1 expression was significantly associated with tumor size, lymph node metastasis, telomerase reverse transcriptase, promoter mutation and recurrence. PINX1 mRNA expression was more pronounced in the recurrent group than in the nonrecurrent group. In addition, results of the binary logistic regression model showed that PINX1 protein expression had a significant influence on recurrence. [PMID:30026037]", "loinc_code": "", "tissue": { "name": "thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "disease": { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] }, "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "30026037", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30026037" } ] }, { "best_biomarker_type": "prognostic", "status": "decreased PINX1 level", "notes": "", "literature_evidence": "PinX1 low expression staining was observed in 7 of 35 (20%) normal renal tissues, and 168 of 278 (60%) ccRCC tissues (P < 0.001) low PinX1 staining correlated with both worse overall and disease-specific survival in ccRCC (P = 0.002 and P = 0.002). [PMID:26033551] To further understand the molecular mechanism of PinX1 in renal cancer angiogenesis, we obtained the gene microarray to determine the downstream molecules of PinX1 in renal cancer. Surprisingly, PinX1 promoted the expression level of miR-125a-3p, which is a tumor suppressor of multiple oncogenes, including VEGF, CDK3, FUT5/6, and ERBB2/3. [PMID:31254127]", "loinc_code": "", "tissue": { "name": "kidney", "namespace": "UBERON", "id": "0002113", "url": "http://purl.obolibrary.org/obo/UBERON_0002113" }, "disease": { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] }, "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "26033551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26033551" }, { "id": "31254127", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31254127" } ] } ], "publication": [ { "title": "The clinical significance of PINX1 expression in papillary thyroid carcinoma.", "journal": "Human pathology", "authors": "Kang J, Han K, Kim HJ, Park JH, Kong JS, Park S, Myung JK", "date": "2018", "reference": [ { "type": "PubMed", "id": "30026037", "url": "https://glygen.org/publication/PubMed/30026037" } ], "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" } ] }, { "title": "PinX1 represses renal cancer angiogenesis via the mir-125a-3p/VEGF signaling pathway.", "journal": "Angiogenesis", "authors": "Hou P, Li H, Yong H, Chen F, Chu S, Zheng J, Bai J", "date": "2019", "reference": [ { "type": "PubMed", "id": "31254127", "url": "https://glygen.org/publication/PubMed/31254127" } ], "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" } ] }, { "title": "PinX1 serves as a potential prognostic indicator for clear cell renal cell carcinoma and inhibits its invasion and metastasis by suppressing MMP-2 via NF-kappaB-dependent transcription.", "journal": "Oncotarget", "authors": "Li HL, Han L, Chen HR, Meng F, Liu QH, Pan ZQ, Bai J, Zheng JN", "date": "2015", "reference": [ { "type": "PubMed", "id": "26033551", "url": "https://glygen.org/publication/PubMed/26033551" } ], "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" } ] } ], "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "30026037", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30026037" }, { "id": "26033551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26033551" }, { "id": "31254127", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31254127" } ], "biomarker_id": "A0324", "aclist": [ "Q96BK5-1" ], "crossref": [], "section_stats": [ { "table_id": "instances", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "best_biomarker_type", "status", "notes", "literature_evidence", "loinc_code", "tissue.name", "tissue.namespace", "tissue.id", "tissue.url", "disease.disease_id" ] }, { "table_id": "components", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "authors", "date" ] } ] }