{
    "assessed_biomarker_entity": "Kallikrein-10 (KLK10)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "O43240-1",
                "name": "Kallikrein-10",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "12591730",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/12591730"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "increased KLK10 level",
            "notes": "Elevated hK10 concentration",
            "literature_evidence": "HK10 concentration is significantly elevated in serum of presurgical ovarian cancer patients (range: 106-11,746 ng/liter; mean = 1067 ng/liter) but not in serum of patients with benign gynecologic diseases (range: 120-1200 ng/liter; mean = 447 ng/liter). Serum hK10 represents a novel biomarker for ovarian cancer. We conclude that preoperative serum hK10 concentration is a strong and independent unfavorable prognostic marker for ovarian cancer. [PMID:12591730]",
            "loinc_code": "",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:2394",
                "recommended_name": {
                    "id": "DOID:2394",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2394",
                    "name": "ovarian cancer",
                    "description": "A female reproductive organ cancer that is located_in the ovary."
                },
                "synonyms": [
                    {
                        "id": "DOID:2394",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:2394",
                        "name": "malignant Ovarian tumor",
                        "description": ""
                    },
                    {
                        "id": "DOID:2394",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:2394",
                        "name": "malignant tumour of ovary",
                        "description": ""
                    },
                    {
                        "id": "DOID:2394",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:2394",
                        "name": "ovarian neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:2394",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:2394",
                        "name": "ovary neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:2394",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:2394",
                        "name": "primary ovarian cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:2394",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:2394",
                        "name": "tumor of the Ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0011931",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                        "name": "ovarian cancer, susceptibility to, 1",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0011931",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                        "name": "OVCAS1",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0011931",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                        "name": "ovarian cancer, susceptibility to",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0011931",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                        "name": "ovarian cancer, susceptibility to, 1",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovarian cancer",
                        "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas."
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovarian neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovary neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "tumor of the ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "cancer of ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "cancer of the ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant neoplasm of ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant neoplasm of the ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant ovarian neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant ovarian tumor",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant ovary neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant tumor of ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant tumor of the ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant tumour of ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovarian cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovarian cancer, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovarian malignant tumor",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovary cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovarian cancer, epithelial",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "primary ovarian cancer",
                        "description": ""
                    },
                    {
                        "id": "MIM:167000",
                        "resource": "MIM",
                        "url": "https://www.omim.org/entry/167000",
                        "name": "Ovarian cancer",
                        "description": "Ovarian cancer"
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "12591730",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/12591730"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "The serum concentration of human kallikrein 10 represents a novel biomarker for ovarian cancer diagnosis and prognosis.",
            "journal": "Cancer research",
            "authors": "Luo LY, Katsaros D, Scorilas A, Fracchioli S, Bellino R, van Gramberen M, de Bruijn H, Henrik A, Stenman UH, Massobrio M, van der Zee AG, Vergote I, Diamandis EP",
            "date": "2003",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12591730",
                    "url": "https://glygen.org/publication/PubMed/12591730"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "12591730",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/12591730"
        }
    ],
    "biomarker_id": "A0317",
    "aclist": [
        "O43240-1"
    ],
    "crossref": [],
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