{
    "assessed_biomarker_entity": "Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4)",
    "assessed_entity_type": "gene",
    "components": {
        "protein": [
            {
                "accession": "O15554-1",
                "name": "Intermediate conductance calcium-activated potassium channel protein 4",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
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                        "id": "32857728",
                        "database": "PubMed",
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        {
            "best_biomarker_type": "prognostic",
            "status": "increased KCNN4 level",
            "notes": "Also a diagnostic biomarker|Upregulation of KCNN4 levels",
            "literature_evidence": "We examined expression of KCNN4 in public databases and discovered that it is upregulated in PTC. These results suggest that KCNN4 promotes PTC progression by inducing epithelial-mesenchymal transition and suppressing apoptosis, which suggests KCNN4 may be a useful diagnostic and prognostic biomarker of PTC. [PMID:32857728]",
            "loinc_code": "",
            "tissue": {
                "name": "thyroid gland",
                "namespace": "UBERON",
                "id": "0002046",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002046"
            },
            "disease": {
                "disease_id": "DOID:1781",
                "recommended_name": {
                    "id": "DOID:1781",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1781",
                    "name": "thyroid gland cancer",
                    "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                },
                "synonyms": [
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "Thyroid gland neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "malignant neoplasm of thyroid gland",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "malignant tumour of thyroid gland",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "neoplasm of thyroid gland",
                        "description": ""
                    },
                    {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "thyroid neoplasm",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "32857728",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32857728"
                }
            ]
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    ],
    "publication": [
        {
            "title": "KCNN4 is a diagnostic and prognostic biomarker that promotes papillary thyroid cancer progression.",
            "journal": "Aging",
            "authors": "Wen J, Lin B, Lin L, Chen Y, Wang O",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32857728",
                    "url": "https://glygen.org/publication/PubMed/32857728"
                }
            ],
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                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
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        {
            "id": "32857728",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32857728"
        }
    ],
    "biomarker_id": "A0291",
    "aclist": [
        "O15554-1"
    ],
    "crossref": [],
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