{
    "assessed_biomarker_entity": "C-X-C chemokine receptor type 4 (CXCR4)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "P61073-1",
                "name": "C-X-C chemokine receptor type 4",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "15756007",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/15756007"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "increased CXCR4 level",
            "notes": "Increased CXCR4 expression",
            "literature_evidence": "The CXCR4 expression on tumor cells was correlated with an unfavorable prognosis with a median disease-free and overall survival of 22 and 35 months, respectively. The hazard ratios of relapse and death, compared with patients with CXCR4-negative tumors, were 2.5 (95% confidence interval, 1.2-6.1) and 3.1 (95% confidence interval, 1.1-7.2), respectively. This article provides the first evidence that CXCR4 expression could be an independent and powerful prognostic marker in primary cutaneous malignant melanomas. [PMID:15756007]",
            "loinc_code": "",
            "tissue": {
                "name": "skin epidermis",
                "namespace": "UBERON",
                "id": "0001003",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001003"
            },
            "disease": {
                "disease_id": "DOID:4159",
                "recommended_name": {
                    "id": "DOID:4159",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:4159",
                    "name": "skin cancer",
                    "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
                },
                "synonyms": [
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "CA - skin cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "malignant neoplasm of skin",
                        "description": ""
                    },
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "melanoma and Non-melanoma skin cancer",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "15756007",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/15756007"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma.",
            "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research",
            "authors": "Scala S, Ottaiano A, Ascierto PA, Cavalli M, Simeone E, Giuliano P, Napolitano M, Franco R, Botti G, Castello G",
            "date": "2005",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15756007",
                    "url": "https://glygen.org/publication/PubMed/15756007"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "15756007",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/15756007"
        }
    ],
    "biomarker_id": "A0270",
    "aclist": [
        "P61073-1"
    ],
    "crossref": [],
    "section_stats": [
        {
            "table_id": "instances",
            "table_stats": [
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            ],
            "sort_fields": [
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}