{
    "assessed_biomarker_entity": "Serine/arginine-related protein 53 (RSRC1)",
    "assessed_entity_type": "gene",
    "components": {
        "protein": [
            {
                "accession": "Q96IZ7-1",
                "name": "Serine/Arginine-related protein 53",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "30532555",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/30532555"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "monitoring",
            "status": "increased RSRC1 level",
            "notes": "High expression of RSRC1 gene",
            "literature_evidence": "At the top middle was the RSRC1 module, which included RSRC1 and FLOT1. Within this module, eight genes (RPS11, RPS14, RPS15, RPS26, RPS28, RPS3, RPS3A, and RPS9) that RSRC1 interacted with were ribosomal protein genes. Ribosome is important for protein biosynthesis, and there have been several reports that downregulation of ribosomal protein can inhibit or attenuate NSCLC growth and migration. [PMID:30532555]",
            "loinc_code": "",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:1324",
                "recommended_name": {
                    "id": "DOID:1324",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1324",
                    "name": "lung cancer",
                    "description": "A respiratory system cancer that is located_in the lung."
                },
                "synonyms": [
                    {
                        "id": "MONDO:0012159",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                        "name": "lung cancer susceptibility 1",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012159",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                        "name": "LNCR1",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012159",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                        "name": "lung cancer susceptibility",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012159",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                        "name": "lung cancer susceptibility 1",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012942",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                        "name": "lung cancer susceptibility 3",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012942",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                        "name": "LNCR3",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012942",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                        "name": "lung cancer susceptibility 3",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012942",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                        "name": "adenocarcinoma of lung, susceptibility to",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012955",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                        "name": "lung cancer susceptibility 4",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012955",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                        "name": "LNCR4",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012955",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                        "name": "lung cancer susceptibility 4",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0013631",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                        "name": "lung cancer susceptibility 5",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0013631",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                        "name": "LNCR5",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0013631",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                        "name": "lung cancer susceptibility 5",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung cancer",
                        "description": "A malignant neoplasm involving the lung."
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "adenocarcinoma of lung, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "cancer of lung",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung cancer, protection against, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung cancer, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant lung neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant lung tumor",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant neoplasm of lung",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant neoplasm of the lung",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant tumor of lung",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant tumor of the lung",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "nonsmall cell lung cancer, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "Nonsmall cell lung cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "alveolar cell carcinoma",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung cancer, protection against",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MIM:211980",
                        "resource": "MIM",
                        "url": "https://www.omim.org/entry/211980",
                        "name": "Lung cancer",
                        "description": "Lung cancer"
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "30532555",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30532555"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Identification of tumor-educated platelet biomarkers of non-small-cell lung cancer.",
            "journal": "OncoTargets and therapy",
            "authors": "Sheng M, Dong Z, Xie Y",
            "date": "2018",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30532555",
                    "url": "https://glygen.org/publication/PubMed/30532555"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "30532555",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/30532555"
        }
    ],
    "biomarker_id": "A0267",
    "aclist": [
        "Q96IZ7-1"
    ],
    "crossref": [],
    "section_stats": [
        {
            "table_id": "instances",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "best_biomarker_type",
                "status",
                "notes",
                "literature_evidence",
                "loinc_code",
                "tissue.name",
                "tissue.namespace",
                "tissue.id",
                "tissue.url",
                "disease.disease_id"
            ]
        },
        {
            "table_id": "components",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}