{
    "assessed_biomarker_entity": "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHB)",
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    },
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        {
            "best_biomarker_type": "predictive",
            "status": "increased PDHB level",
            "notes": "",
            "literature_evidence": "The PDHB module, which was involved in carbohydrate metabolism. The PDHB module interacted with the RSRC1 module, which was associated with protein biosynthesis, growth, and migration. These biomarkers can accurately predict NSCLC. In-depth biological network analysis suggested that there were four modules and three intermodule hubs that may trigger NSCLC [PMID:30532555].",
            "loinc_code": "",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:1324",
                "recommended_name": {
                    "id": "DOID:1324",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1324",
                    "name": "lung cancer",
                    "description": "A respiratory system cancer that is located_in the lung."
                },
                "synonyms": [
                    {
                        "id": "MONDO:0012159",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012159",
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                        "description": ""
                    },
                    {
                        "id": "MONDO:0012159",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                        "name": "LNCR1",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012159",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                        "name": "lung cancer susceptibility",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012159",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                        "name": "lung cancer susceptibility 1",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012942",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                        "name": "lung cancer susceptibility 3",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012942",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                        "name": "LNCR3",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012942",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                        "name": "lung cancer susceptibility 3",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012942",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                        "name": "adenocarcinoma of lung, susceptibility to",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012955",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                        "name": "lung cancer susceptibility 4",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012955",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                        "name": "LNCR4",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0012955",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                        "name": "lung cancer susceptibility 4",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0013631",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                        "name": "lung cancer susceptibility 5",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0013631",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                        "name": "LNCR5",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0013631",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                        "name": "lung cancer susceptibility 5",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung cancer",
                        "description": "A malignant neoplasm involving the lung."
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "adenocarcinoma of lung, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "cancer of lung",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung cancer, protection against, autosomal dominant, somatic mutation",
                        "description": ""
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                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
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                        "name": "lung cancer, somatic",
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                    {
                        "id": "MONDO:0008903",
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                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
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                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant lung neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant lung tumor",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant neoplasm of lung",
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                    },
                    {
                        "id": "MONDO:0008903",
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                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant neoplasm of the lung",
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                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant tumor of lung",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "malignant tumor of the lung",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "nonsmall cell lung cancer, somatic",
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                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
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                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
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                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "alveolar cell carcinoma",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung cancer, protection against",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008903",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                        "name": "lung neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MIM:211980",
                        "resource": "MIM",
                        "url": "https://www.omim.org/entry/211980",
                        "name": "Lung cancer",
                        "description": "Lung cancer"
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "30532555",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30532555"
                }
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    ],
    "publication": [
        {
            "title": "Identification of tumor-educated platelet biomarkers of non-small-cell lung cancer.",
            "journal": "OncoTargets and therapy",
            "authors": "Sheng M, Dong Z, Xie Y",
            "date": "2018",
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                {
                    "type": "PubMed",
                    "id": "30532555",
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            "id": "30532555",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/30532555"
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    ],
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    ],
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