{
    "assessed_biomarker_entity": "Fourier transform infrared spectroscopy RNA to DNA ratio (FTIR RNA to DNA)",
    "assessed_entity_type": "DNA|RNA",
    "components": {
        "protein": [
            {
                "accession": "Q6P1J9-1",
                "name": "Parafibromin",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
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                        "id": "15230879",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/15230879"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "increased FTIR RNA to DNA ratio",
            "notes": "NCIt:C0028606",
            "literature_evidence": "The cancerous cells had a clear increased RNA/DNA ratio. The RNA/DNA ratio was equal or greater for the melanoma of patient no. 6. In the group of patients studied, tumour thickness did not exceed the limit of 0.75 mm. Because these melanomas were present on the skin surface and within the epidermis, we assume that the absorbance due to collagen would not significantly affect the values. The absence of collagen was further verified by the absence of peaks in the second derivative spectra of the samples at the characteristic wave numbers. [PMID:15230879]",
            "loinc_code": "",
            "tissue": {
                "name": "epithelium",
                "namespace": "UBERON",
                "id": "0000483",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000483"
            },
            "disease": {
                "disease_id": "DOID:4159",
                "recommended_name": {
                    "id": "DOID:4159",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:4159",
                    "name": "skin cancer",
                    "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
                },
                "synonyms": [
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "CA - skin cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "malignant neoplasm of skin",
                        "description": ""
                    },
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "melanoma and Non-melanoma skin cancer",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "15230879",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/15230879"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Possible common biomarkers from FTIR microspectroscopy of cervical cancer and melanoma.",
            "journal": "Journal of microscopy",
            "authors": "Mordechai S, Sahu R K, Hammody Z, Mark S, Kantarovich K, Guterman H, Podshyvalov A, Goldstein J, Argov S",
            "date": "2004-07",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15230879",
                    "url": "https://glygen.org/publication/PubMed/15230879"
                }
            ],
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                    "id": "GLY_000625",
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                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
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            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "15230879",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/15230879"
        }
    ],
    "biomarker_id": "A0239",
    "aclist": [
        "Q6P1J9-1"
    ],
    "crossref": [],
    "section_stats": [
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}