{
    "assessed_biomarker_entity": "Leucine-rich alpha-2-glycoprotein 1 (LRAG1)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "P02750-1",
                "name": "Leucine-rich alpha-2-glycoprotein",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "31582665",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/31582665"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "predictive",
            "status": "increased LRAG1 level",
            "notes": "",
            "literature_evidence": "Among them, the serum levels of leucine-rich alpha-2-glycoprotein 1 (LRG1) were significantly different (p < 0.01) and well discriminated (area under the curve (AUC) of the receiver operating characteristic (ROC) curve >0.8) between responder and non-responder groups. The present results suggest that LRG1 and its combination with CRP and sIL-6R are promising biomarker candidates to predict response to PCRT in esophageal cancer patients. [PMID:31582665]",
            "loinc_code": "",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:5041",
                "recommended_name": {
                    "id": "DOID:5041",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:5041",
                    "name": "esophageal cancer",
                    "description": "A gastrointestinal system cancer that is located_in the esophagus."
                },
                "synonyms": [
                    {
                        "id": "DOID:5041",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:5041",
                        "name": "Ca lower third oesophagus",
                        "description": ""
                    },
                    {
                        "id": "DOID:5041",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:5041",
                        "name": "Ca middle third oesophagus",
                        "description": ""
                    },
                    {
                        "id": "DOID:5041",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:5041",
                        "name": "esophagus cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:5041",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:5041",
                        "name": "malignant neoplasm of distal third of esophagus",
                        "description": ""
                    },
                    {
                        "id": "DOID:5041",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:5041",
                        "name": "malignant neoplasm of lower third of oesophagus",
                        "description": ""
                    },
                    {
                        "id": "DOID:5041",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:5041",
                        "name": "malignant neoplasm of middle third of oesophagus",
                        "description": ""
                    },
                    {
                        "id": "DOID:5041",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:5041",
                        "name": "malignant neoplasm of proximal third of esophagus",
                        "description": ""
                    },
                    {
                        "id": "DOID:5041",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:5041",
                        "name": "malignant neoplasm of upper third esophagus",
                        "description": ""
                    },
                    {
                        "id": "DOID:5041",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:5041",
                        "name": "malignant tumor of Distal Third of esophagus",
                        "description": ""
                    },
                    {
                        "id": "DOID:5041",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:5041",
                        "name": "malignant tumor of Proximal Third of esophagus",
                        "description": ""
                    },
                    {
                        "id": "DOID:5041",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:5041",
                        "name": "malignant tumor of abdominal esophagus",
                        "description": ""
                    },
                    {
                        "id": "DOID:5041",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:5041",
                        "name": "malignant tumor of the middle Third of the esophagus",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "esophageal cancer",
                        "description": "A primary or metastatic malignant neoplasm involving the esophagus."
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "cancer of esophagus",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "esophageal cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "esophageal cancer, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "esophageal carcinoma, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "esophageal squamous cell carcinoma, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "esophagus cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "malignant esophageal neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "malignant esophageal tumor",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "malignant esophagus neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "malignant esophagus tumor",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "malignant neoplasm of esophagus",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "malignant neoplasm of the esophagus",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "malignant tumor of esophagus",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "malignant tumor of the esophagus",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "Ca lower third oesophagus",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "Ca middle third oesophagus",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "malignant neoplasm of distal third of esophagus",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "malignant neoplasm of lower third of oesophagus",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "malignant neoplasm of middle third of oesophagus",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "malignant neoplasm of proximal third of esophagus",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "malignant neoplasm of upper third esophagus",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "malignant tumor of abdominal esophagus",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "malignant tumor of distal third of esophagus",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "malignant tumor of proximal third of esophagus",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "malignant tumor of the middle third of the esophagus",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "Aerodigestive tract cancer, susceptibility to",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "Escc, susceptibility to",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "esophageal squamous cell carcinoma, susceptibility to",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0007576",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                        "name": "gastric cardia adenocarcinoma, susceptibility to",
                        "description": ""
                    },
                    {
                        "id": "MIM:133239",
                        "resource": "MIM",
                        "url": "https://www.omim.org/entry/133239",
                        "name": "Esophageal cancer",
                        "description": "Esophageal cancer"
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "31582665",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31582665"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Leucine-Rich Alpha-2-Glycoprotein 1 in Serum Is a Possible Biomarker to Predict Response to Preoperative Chemoradiotherapy for Esophageal Cancer.",
            "journal": "Biological & pharmaceutical bulletin",
            "authors": "Nambu M, Masuda T, Ito S, Kato K, Kojima T, Daiko H, Ito Y, Honda K, Ohtsuki S",
            "date": "2019",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31582665",
                    "url": "https://glygen.org/publication/PubMed/31582665"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "31582665",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/31582665"
        }
    ],
    "biomarker_id": "A0228",
    "aclist": [
        "P02750-1"
    ],
    "crossref": [],
    "section_stats": [
        {
            "table_id": "instances",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "best_biomarker_type",
                "status",
                "notes",
                "literature_evidence",
                "loinc_code",
                "tissue.name",
                "tissue.namespace",
                "tissue.id",
                "tissue.url",
                "disease.disease_id"
            ]
        },
        {
            "table_id": "components",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}