{
    "assessed_biomarker_entity": "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (C1GALT1)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "Q9NS00-1",
                "name": "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1",
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                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
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        {
            "best_biomarker_type": "prognostic",
            "status": "increased C1GALT1 level",
            "notes": "Head and neck squamous cell carcinoma (HNSCC)|Upregulated C1GALT1 expression",
            "literature_evidence": "C1GALT1 expression is upregulated in HNSCC tumors and is associated with adverse clinicopathologic features. Moreover, high C1GALT1 expression predicts poor disease-free and overall survivals. For Kaplan-Meier analysis, we further classified C1GALT1 scores 0-1 and scores 2-3 as low and high expression, respectively. Results showed that high C1GALT1 expression was significantly associated with poor disease-free survival and overall survival. [PMID:29930379]",
            "loinc_code": "",
            "tissue": {
                "name": "squamous epithelium",
                "namespace": "UBERON",
                "id": "0006914",
                "url": "http://purl.obolibrary.org/obo/UBERON_0006914"
            },
            "disease": {
                "disease_id": "DOID:11934",
                "recommended_name": {
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                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:11934",
                    "name": "head and neck cancer",
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                },
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                        "id": "DOID:11934",
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                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "head and neck neoplasm",
                        "description": ""
                    },
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                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "head and neck tumours",
                        "description": ""
                    },
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                        "id": "DOID:11934",
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                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "head/neck neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "tumor of head and neck",
                        "description": ""
                    }
                ]
            },
            "evidence": [
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                    "url": "https://data.glygen.org/GLY_000625"
                },
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                    "id": "29930379",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/29930379"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "C1GALT1 predicts poor prognosis and is a potential therapeutic target in head and neck cancer.",
            "journal": "Oncogene",
            "authors": "Lin MC, Chien PH, Wu HY, Chen ST, Juan HF, Lou PJ, Huang MC",
            "date": "2018",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "29930379",
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                }
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        }
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    ],
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