{
    "assessed_biomarker_entity": "Acid sphingomyelinase (SMPD1)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "P17405-1",
                "name": "Sphingomyelin phosphodiesterase",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "26125272",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/26125272"
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                ]
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        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "diagnostic",
            "status": "decreased SMPD1 level",
            "notes": "This biomarker is considered a negative biomarker",
            "literature_evidence": "The levels of ASM were reducing with the development of ovarian cancer. ASM is higher expressed in normal cell than that in ovarian cancer, and can be a negative biomarker for the diagnosis of ovarian cancer. ASM can be developed a new drug for the ovarian cancer therapy. [PMID:26125272]",
            "loinc_code": "",
            "tissue": {
                "name": "ovary",
                "namespace": "UBERON",
                "id": "0000992",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000992"
            },
            "disease": {
                "disease_id": "DOID:2394",
                "recommended_name": {
                    "id": "DOID:2394",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2394",
                    "name": "ovarian cancer",
                    "description": "A female reproductive organ cancer that is located_in the ovary."
                },
                "synonyms": [
                    {
                        "id": "DOID:2394",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:2394",
                        "name": "malignant Ovarian tumor",
                        "description": ""
                    },
                    {
                        "id": "DOID:2394",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:2394",
                        "name": "malignant tumour of ovary",
                        "description": ""
                    },
                    {
                        "id": "DOID:2394",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:2394",
                        "name": "ovarian neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:2394",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:2394",
                        "name": "ovary neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:2394",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:2394",
                        "name": "primary ovarian cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:2394",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:2394",
                        "name": "tumor of the Ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0011931",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                        "name": "ovarian cancer, susceptibility to, 1",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0011931",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                        "name": "OVCAS1",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0011931",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                        "name": "ovarian cancer, susceptibility to",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0011931",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                        "name": "ovarian cancer, susceptibility to, 1",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovarian cancer",
                        "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas."
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovarian neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovary neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "tumor of the ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "cancer of ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "cancer of the ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant neoplasm of ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant neoplasm of the ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant ovarian neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant ovarian tumor",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant ovary neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant tumor of ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant tumor of the ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "malignant tumour of ovary",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovarian cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovarian cancer, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovarian malignant tumor",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovary cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "ovarian cancer, epithelial",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0008170",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                        "name": "primary ovarian cancer",
                        "description": ""
                    },
                    {
                        "id": "MIM:167000",
                        "resource": "MIM",
                        "url": "https://www.omim.org/entry/167000",
                        "name": "Ovarian cancer",
                        "description": "Ovarian cancer"
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "26125272",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/26125272"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Acid sphingomyelinase, a novel negative biomarker of ovarian cancer.",
            "journal": "European review for medical and pharmacological sciences",
            "authors": "Dai SY, Liu JJ, Sun XF, Wang N",
            "date": "2015",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26125272",
                    "url": "https://glygen.org/publication/PubMed/26125272"
                }
            ],
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                    "url": "https://data.glygen.org/GLY_000625"
                }
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        }
    ],
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            "id": "GLY_000625",
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        {
            "id": "26125272",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/26125272"
        }
    ],
    "biomarker_id": "A0205",
    "aclist": [
        "P17405-1"
    ],
    "crossref": [],
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