{
    "assessed_biomarker_entity": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (ST6GALNAC6)",
    "assessed_entity_type": "gene",
    "components": {
        "protein": [
            {
                "accession": "Q969X2-1",
                "name": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
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                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/30131287"
                    }
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            }
        ],
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    },
    "instances": [
        {
            "best_biomarker_type": "diagnostic",
            "status": "increased ST6GALNAC6 level",
            "notes": "",
            "literature_evidence": "In patients with pancreatic cancer, 8.4% of subjects were Lewis (-), but only 41.9% of Lewis (-) subjects had CA19-9 values </= 2 U/mL. CA19-9 was even elevated (>37 U/mL) in 27.4% of Lewis (-) patients. CA19-9 can retain its utility as a biomarker in these patients in spite of Lewis (-) genotype. The area under the receiver operating characteristic (ROC) curve for CA19-9 as a diagnostic biomarker was 0.842 in Lewis (-) patients with pancreatic cancer. [PMID:30131287]",
            "loinc_code": "",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:1793",
                "recommended_name": {
                    "id": "DOID:1793",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1793",
                    "name": "pancreatic cancer",
                    "description": "An endocrine gland cancer located_in the pancreas."
                },
                "synonyms": [
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "Ca body of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "Ca head of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "Ca tail of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "malignant neoplasm of body of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "malignant neoplasm of head of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "malignant neoplasm of tail of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "pancreas neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "pancreatic neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "pancreatic tumor",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "30131287",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30131287"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "New observations on the utility of CA19-9 as a biomarker in Lewis negative patients with pancreatic cancer.",
            "journal": "Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]",
            "authors": "Luo G, Fan Z, Cheng H, Jin K, Guo M, Lu Y, Yang C, Fan K, Huang Q, Long J, Liu L, Xu J, Lu R, Ni Q, Warshaw AL, Liu C, Yu X",
            "date": "2018",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30131287",
                    "url": "https://glygen.org/publication/PubMed/30131287"
                }
            ],
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                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
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            "id": "GLY_000625",
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            "url": "https://data.glygen.org/GLY_000625"
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        {
            "id": "30131287",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/30131287"
        }
    ],
    "biomarker_id": "A0202",
    "aclist": [
        "Q969X2-1"
    ],
    "crossref": [],
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