{
    "assessed_biomarker_entity": "Receptor-type tyrosine-protein phosphatase mu (PTPRM)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "P28827-1",
                "name": "Receptor-type tyrosine-protein phosphatase mu",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "32663515",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/32663515"
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        ],
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    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "decreased PTPRM level",
            "notes": "PTPRM biomarker in pancreatic ductal adenocarcinoma",
            "literature_evidence": "This exploratory study, using SWATH-MS analysis, identified potential prognostic biomarkers for PDAC in plasma (PTPRM and PTPRB) and plasma derived microparticles (PSMD11). Protein tyrosine phosphatases, PTPRM and PTPRB, were decreased in plasma of patients with poor PDAC prognosis, while proteasomal subunit PSMD11 was increased in microparticles of patients with poor prognosis. [PMID:32663515]",
            "loinc_code": "",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:1793",
                "recommended_name": {
                    "id": "DOID:1793",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1793",
                    "name": "pancreatic cancer",
                    "description": "An endocrine gland cancer located_in the pancreas."
                },
                "synonyms": [
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "Ca body of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "Ca head of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "Ca tail of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "malignant neoplasm of body of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "malignant neoplasm of head of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "malignant neoplasm of tail of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "pancreas neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "pancreatic neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "pancreatic tumor",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "32663515",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32663515"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression.",
            "journal": "Biochimica et biophysica acta. General subjects",
            "authors": "Sahni S, Krisp C, Molloy MP, Nahm C, Maloney S, Gillson J, Gill AJ, Samra J, Mittal A",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32663515",
                    "url": "https://glygen.org/publication/PubMed/32663515"
                }
            ],
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                    "id": "GLY_000625",
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                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
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        {
            "id": "32663515",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32663515"
        }
    ],
    "biomarker_id": "A0198",
    "aclist": [
        "P28827-1"
    ],
    "crossref": [],
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