{
    "assessed_biomarker_entity": "Neutral cholesterol ester hydrolase 1 (NCEH1)",
    "assessed_entity_type": "gene",
    "components": {
        "protein": [
            {
                "accession": "Q6PIU2-1",
                "name": "Neutral cholesterol ester hydrolase 1",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "33284889",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/33284889"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "increased NCEH1 level",
            "notes": "High NCEH1 expression",
            "literature_evidence": "Elevated ether lipid metabolism is one of the characteristics of cancer cells. NCEH1 is involved in ether lipid metabolism and is robustly expressed in macrophages. We also found that the expression level of NCEH1 in patients with pancreatic cancer is related to the N classification (P = 0.039), indicating that patients with local lymph node involvement express higher levels of NCEH1. From the differential analysis, the expression level of NCEH1 in cancer tissues was significantly higher than that in healthy tissues (P = 1.732 e-50) Wilcoxon test indicated that the expression level of NCEH1 is related to the N classification in patients with pancreatic cancer (P = 0.039). Further, NCEH1 expression was higher in patients with regional lymph node involvement than in the control group. [PMID:33284889]",
            "loinc_code": "",
            "tissue": {
                "name": "pancreas",
                "namespace": "UBERON",
                "id": "0001264",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001264"
            },
            "disease": {
                "disease_id": "DOID:1793",
                "recommended_name": {
                    "id": "DOID:1793",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1793",
                    "name": "pancreatic cancer",
                    "description": "An endocrine gland cancer located_in the pancreas."
                },
                "synonyms": [
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "Ca body of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "Ca head of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "Ca tail of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "malignant neoplasm of body of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "malignant neoplasm of head of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "malignant neoplasm of tail of pancreas",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "pancreas neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "pancreatic neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:1793",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1793",
                        "name": "pancreatic tumor",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "33284889",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/33284889"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "NCEH1 may be a prognostic biomarker for pancreatic cancer.",
            "journal": "International journal of clinical and experimental pathology",
            "authors": "Lu Y, Zhang L, Chen X, Zhang Q",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33284889",
                    "url": "https://glygen.org/publication/PubMed/33284889"
                }
            ],
            "evidence": [
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                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
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            "id": "GLY_000625",
            "database": "GlyGen",
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        },
        {
            "id": "33284889",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/33284889"
        }
    ],
    "biomarker_id": "A0194",
    "aclist": [
        "Q6PIU2-1"
    ],
    "crossref": [],
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