{
    "assessed_biomarker_entity": "Alpha-1-antitrypsin (A1AT)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "P01009-1",
                "name": "Alpha-1-antitrypsin",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "21459797",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/21459797"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "diagnostic",
            "status": "increased A1AT level",
            "notes": "",
            "literature_evidence": "Increased levels of urinary A1AT glycoprotein were indicative of the presence of bladder cancer (P < 0.0001) and augmented voided urine cytology results. Application of glycoprotein enrichment provided novel candidates for further investigation as biomarkers for the noninvasive detection of bladder cancer. [PMID:21459797]",
            "loinc_code": "",
            "tissue": {
                "name": "urine",
                "namespace": "UBERON",
                "id": "0001088",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001088"
            },
            "disease": {
                "disease_id": "DOID:11054",
                "recommended_name": {
                    "id": "DOID:11054",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:11054",
                    "name": "urinary bladder cancer",
                    "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
                },
                "synonyms": [
                    {
                        "id": "DOID:11054",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11054",
                        "name": "bladder cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:11054",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11054",
                        "name": "tumor of the bladder",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "urinary bladder cancer",
                        "description": "A primary or metastatic malignant neoplasm involving the bladder."
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "tumor of the bladder",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "bladder cancer, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "cancer of urinary bladder",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "malignant bladder neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "malignant bladder tumor",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "malignant neoplasm of bladder",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "malignant neoplasm of the bladder",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "malignant neoplasm of the urinary bladder",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "malignant neoplasm of urinary bladder",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "malignant neoplasm, bladder",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "malignant neoplasm, urinary bladder",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "malignant tumor of bladder",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "malignant tumor of the bladder",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "malignant tumor of the urinary bladder",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "malignant tumor of urinary bladder",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "malignant tumor, urinary bladder",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "malignant urinary bladder neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "malignant urinary bladder tumor",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "urinary bladder cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "urinary bladder malignant neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001187",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                        "name": "urinary bladder malignant tumor",
                        "description": ""
                    },
                    {
                        "id": "MIM:109800",
                        "resource": "MIM",
                        "url": "https://www.omim.org/entry/109800",
                        "name": "Bladder cancer",
                        "description": "Bladder cancer"
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "21459797",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/21459797"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Urinary glycoprotein biomarker discovery for bladder cancer detection using LC/MS-MS and label-free quantification.",
            "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research",
            "authors": "Yang N, Feng S, Shedden K, Xie X, Liu Y, Rosser CJ, Lubman DM, Goodison S",
            "date": "2011",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21459797",
                    "url": "https://glygen.org/publication/PubMed/21459797"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "21459797",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/21459797"
        }
    ],
    "biomarker_id": "A0191",
    "aclist": [
        "P01009-1"
    ],
    "crossref": [],
    "section_stats": [
        {
            "table_id": "instances",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "best_biomarker_type",
                "status",
                "notes",
                "literature_evidence",
                "loinc_code",
                "tissue.name",
                "tissue.namespace",
                "tissue.id",
                "tissue.url",
                "disease.disease_id"
            ]
        },
        {
            "table_id": "components",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}
