{
    "assessed_biomarker_entity": "BCL2/Adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "O60238-1",
                "name": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "32620611",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/32620611"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "increased BNIP3L level",
            "notes": "Higher levels of BNIP3L indicate a good prognosis in patients treated by AGI-101H|Increased expression of BNIP3L.",
            "literature_evidence": "A specific antibody response was raised against an antigen identified as BNIP3L, which correlated with a good prognosis. Medium and high expression of BNIP3L was also linked with longer overall survival. BNIP3L is a candidate prognostic marker of clinical outcome of melanoma patients treated with AGI-101H, and may be considered as a prediction marker for patient survival. [PMID:32620611]",
            "loinc_code": "",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:4159",
                "recommended_name": {
                    "id": "DOID:4159",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:4159",
                    "name": "skin cancer",
                    "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
                },
                "synonyms": [
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "CA - skin cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "malignant neoplasm of skin",
                        "description": ""
                    },
                    {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "melanoma and Non-melanoma skin cancer",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "32620611",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32620611"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "BNIP3L Is a New Autophagy Related Prognostic Biomarker for Melanoma Patients Treated With AGI-101H.",
            "journal": "Anticancer research",
            "authors": "Kazimierczak U, Kolenda T, Kowalczyk D, Mackiewicz J, Mackiewicz A",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32620611",
                    "url": "https://glygen.org/publication/PubMed/32620611"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "32620611",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32620611"
        }
    ],
    "biomarker_id": "A0178",
    "aclist": [
        "O60238-1"
    ],
    "crossref": [],
    "section_stats": [
        {
            "table_id": "instances",
            "table_stats": [
                {
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                    "count": 1
                }
            ],
            "sort_fields": [
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                "tissue.id",
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        },
        {
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}