{
    "assessed_biomarker_entity": "Deoxycytidine kinase (DCK)",
    "assessed_entity_type": "gene",
    "components": {
        "protein": [
            {
                "accession": "P27707-1",
                "name": "Deoxycytidine kinase",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "32588770",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/32588770"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "increased DCK level",
            "notes": "Upregulation of deoxycytidine kinase",
            "literature_evidence": "The deoxycytidine kinase messenger RNA level significantly upregulated in patients with liver cancer compared to normal liver samples. All the above findings suggested that increased expression of deoxycytidine kinase was significantly related to unfavorable prognosis in patients with liver cancer. Deoxycytidine kinase is correlated with immune infiltrating levels, including those of B cells, macrophages, neutrophils, and dendritic cells in patients with liver cancer. The survival curves revealed that in patients with liver cancer, the high expression level of DCK (RNA-SeqID:1633) indicated worse prognosis. high expression of DCK resulted in shorter OS (HR = 1.90, 95% CI = 1.32-2.72, P value = .00043) and RFS (HR = 1.53, 95% CI = 1.10-2.13, P value = .011). [PMID:32588770]",
            "loinc_code": "",
            "tissue": {
                "name": "liver",
                "namespace": "UBERON",
                "id": "0002107",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002107"
            },
            "disease": {
                "disease_id": "DOID:3571",
                "recommended_name": {
                    "id": "DOID:3571",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3571",
                    "name": "liver cancer",
                    "description": "A hepatobiliary system cancer that is located_in the liver."
                },
                "synonyms": [
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "Ca liver - primary",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "Resectable malignant neoplasm of Liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "hepatic cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "hepatic neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant hepato-biliary neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant neoplasm of liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant neoplasm of liver, primary",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant tumor of liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "neoplasm of liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "non-resectable primary hepatic malignant neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "primary liver cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "primary malignant neoplasm of liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "resectable malignant neoplasm of the liver",
                        "description": ""
                    },
                    {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "malignant neoplasm of liver, not specified as primary or secondary",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "32588770",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32588770"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "DCK is an Unfavorable Prognostic Biomarker and Correlated With Immune Infiltrates in Liver Cancer.",
            "journal": "Technology in cancer research & treatment",
            "authors": "Hu SF, Lin X, Xu LP, Chen HG, Guo JF, Jin L",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32588770",
                    "url": "https://glygen.org/publication/PubMed/32588770"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "32588770",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32588770"
        }
    ],
    "biomarker_id": "A0166",
    "aclist": [
        "P27707-1"
    ],
    "crossref": [],
    "section_stats": [
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        {
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}