{
    "assessed_biomarker_entity": "Selenoprotein P (SELENOP)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "P49908-1",
                "name": "Selenoprotein P",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "32708526",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/32708526"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "decreased SELENOP level",
            "notes": "Measured in serum (UN:0001977) as well.",
            "literature_evidence": "The Se status was significantly higher in samples from surviving COVID patients as compared with non-survivors (Se; 53.3 \u00b1 16.2 vs. 40.8 \u00b1 8.1 \u00b5g/L, SELENOP; 3.3 \u00b1 1.3 vs. 2.1 \u00b1 0.9 mg/L), recovering with time in survivors while remaining low or even declining in non-survivors. We conclude that Se status analysis in COVID patients provides diagnostic information patients suffering from COVID-19 display a deficiency in the essential trace element Se in blood, along with low concentrations of the Se transporter SELENOP and low enzymatic activity of the secreted GPx3. [PMID:32708526]",
            "loinc_code": "",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:0080600",
                "recommended_name": {
                    "id": "DOID:0080600",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080600",
                    "name": "COVID-19",
                    "description": "A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2."
                },
                "synonyms": [
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019 Novel Coronavirus (2019-nCoV)",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019-nCoV infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan coronavirus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan seafood market pneumonia virus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "COVID19",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "SARS-CoV-2 infection",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "32708526",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32708526"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Selenium Deficiency Is Associated with Mortality Risk from COVID-19.",
            "journal": "Nutrients",
            "authors": "Moghaddam A, Heller RA, Sun Q, Seelig J, Cherkezov A, Seibert L, Hackler J, Seemann P, Diegmann J, Pilz M, Bachmann M, Minich WB, Schomburg L",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32708526",
                    "url": "https://glygen.org/publication/PubMed/32708526"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "32708526",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32708526"
        }
    ],
    "biomarker_id": "A0148",
    "aclist": [
        "P49908-1"
    ],
    "crossref": [],
    "section_stats": [
        {
            "table_id": "instances",
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                    "count": 1
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            "sort_fields": [
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        {
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}