{
    "assessed_biomarker_entity": "Complement C5A (C5)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "P01031-1",
                "name": "Complement C5",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "33123364",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/33123364"
                    },
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                        "id": "29423024",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/29423024"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "increased C5 level",
            "notes": "Measured in plasma (UN:0001969) as well.",
            "literature_evidence": "We identified elevated levels of plasma C3a and C5a in HD patients with severe COVID-19 compared with controls. Serial sampling identified that C5a levels were elevated prior to clinical deterioration in patients who developed severe disease. C3a more closely mirrored both clinical and biochemical disease severity. [PMID:33123364]",
            "loinc_code": "4505-4",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:0080600",
                "recommended_name": {
                    "id": "DOID:0080600",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080600",
                    "name": "COVID-19",
                    "description": "A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2."
                },
                "synonyms": [
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019 Novel Coronavirus (2019-nCoV)",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019-nCoV infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan coronavirus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan seafood market pneumonia virus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "COVID19",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "SARS-CoV-2 infection",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "33123364",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/33123364"
                }
            ]
        },
        {
            "best_biomarker_type": "prognostic",
            "status": "increased C5 level",
            "notes": "Measured in serum (UN:0001977) as well|oral squamous cell carcinoma (DOID:0050866)",
            "literature_evidence": "Higher C5a concentrations correlated with tumor differentiation and OSCC extension state. [PMID:29423024]",
            "loinc_code": "4505-4",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:11934",
                "recommended_name": {
                    "id": "DOID:11934",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:11934",
                    "name": "head and neck cancer",
                    "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
                },
                "synonyms": [
                    {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "head and neck neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "head and neck tumours",
                        "description": ""
                    },
                    {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "head/neck neoplasm",
                        "description": ""
                    },
                    {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "tumor of head and neck",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "29423024",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/29423024"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Temporal changes in complement activation in haemodialysis patients with COVID-19 as a predictor of disease progression.",
            "journal": "Clinical kidney journal",
            "authors": "Prendecki Maria, Clarke Candice, Medjeral-Thomas Nicholas, McAdoo Stephen P, Sandhu Eleanor, Peters James E, Thomas David C, Willicombe Michelle, Botto Marina, Pickering Matthew C",
            "date": "2020-10",
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                {
                    "type": "PubMed",
                    "id": "33123364",
                    "url": "https://glygen.org/publication/PubMed/33123364"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        },
        {
            "title": "A novel multiplex detection array revealed systemic complement activation in oral squamous cell carcinoma.",
            "journal": "Oncotarget",
            "authors": "Gallenkamp J, Spanier G, Worle E, Englbrecht M, Kirschfink M, Greslechner R, Braun R, Schafer N, Bauer RJ, Pauly D",
            "date": "2018",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "29423024",
                    "url": "https://glygen.org/publication/PubMed/29423024"
                }
            ],
            "evidence": [
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                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
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    ],
    "evidence": [
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            "id": "GLY_000625",
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        {
            "id": "29423024",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/29423024"
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    ],
    "biomarker_id": "A0140",
    "aclist": [
        "P01031-1"
    ],
    "crossref": [],
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