{
    "assessed_biomarker_entity": "P-selectin (SELP)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "P16109-1",
                "name": "P-selectin",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "32757722",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/32757722"
                    },
                    {
                        "id": "32619411",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/32619411"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "prognostic",
            "status": "increased SELP level",
            "notes": "Measured in plasma (UN:0001969) as well.",
            "literature_evidence": "Biomarkers of platelet activity and vascular health are significantly associated with the composite outcome of thrombosis or death in hospitalized patients with COVID-19. P-selectin and sCD40L contribute to thrombosis by supporting platelet-myeloid heteroaggregate formation and thrombi stability by interaction with PSGL-1 and alpha IIb beta3, respectively. [PMID:32757722]",
            "loinc_code": "17181-9",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:0080600",
                "recommended_name": {
                    "id": "DOID:0080600",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080600",
                    "name": "COVID-19",
                    "description": "A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2."
                },
                "synonyms": [
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019 Novel Coronavirus (2019-nCoV)",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019-nCoV infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan coronavirus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan seafood market pneumonia virus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "COVID19",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "SARS-CoV-2 infection",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "32757722",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32757722"
                },
                {
                    "id": "32619411",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32619411"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "Platelet and Vascular Biomarkers Associate With Thrombosis and Death in Coronavirus Disease.",
            "journal": "Circulation research",
            "authors": "Barrett TJ, Lee AH, Xia Y, Lin LH, Black M, Cotzia P, Hochman J, Berger JS",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32757722",
                    "url": "https://glygen.org/publication/PubMed/32757722"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        },
        {
            "title": "Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study.",
            "journal": "The Lancet. Haematology",
            "authors": "Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32619411",
                    "url": "https://glygen.org/publication/PubMed/32619411"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        }
    ],
    "evidence": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "32757722",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32757722"
        },
        {
            "id": "32619411",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32619411"
        }
    ],
    "biomarker_id": "A0118",
    "aclist": [
        "P16109-1"
    ],
    "crossref": [],
    "section_stats": [
        {
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}