{
    "assessed_biomarker_entity": "Cardiac troponin I (TNNI3)",
    "assessed_entity_type": "protein",
    "components": {
        "protein": [
            {
                "accession": "P19429-1",
                "name": "Troponin I, cardiac muscle",
                "evidence": [
                    {
                        "id": "GLY_000625",
                        "database": "GlyGen",
                        "url": "https://data.glygen.org/GLY_000625"
                    },
                    {
                        "id": "32169400",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/32169400"
                    },
                    {
                        "id": "32530509",
                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/32530509"
                    },
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                        "url": "https://glygen.org/publication/PubMed/32171076"
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                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/32475810"
                    },
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                        "database": "PubMed",
                        "url": "https://glygen.org/publication/PubMed/32251612"
                    }
                ]
            }
        ],
        "glycan": []
    },
    "instances": [
        {
            "best_biomarker_type": "monitoring",
            "status": "increased TNNI3 level",
            "notes": "",
            "literature_evidence": "cTnI values are significantly increased in patients with severe SARS-CoV-2 infection compared to those with milder forms of disease. It is hence reasonable to hypothesize that initial measurement of cardiac damage biomarkers immediately after hospitalization for SARS-CoV-2 infection, as well as longitudinal monitoring during hospital stay, may help identifying a subset of patients with possible cardiac injury and thereby predict the progression of COVID-19 towards a worse clinical picture. [PMID:32169400] High troponin I levels with either advanced age more than 60 years or elevated AST levels was the best model to predict poor outcomes. [PMID:32530509] Age, comorbidities, lymphocytopenia and elevated alanine aminotransferase, d-dimer, creatine kinase, high-sensitivity cardiac troponin I, prothrombin time, and disease severity were reported to be associated with intensive care unit admission. [PMID:32171076]",
            "loinc_code": "10839-9",
            "tissue": {
                "name": "blood",
                "namespace": "UBERON",
                "id": "0000178",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178"
            },
            "disease": {
                "disease_id": "DOID:0080600",
                "recommended_name": {
                    "id": "DOID:0080600",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080600",
                    "name": "COVID-19",
                    "description": "A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2."
                },
                "synonyms": [
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019 Novel Coronavirus (2019-nCoV)",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "2019-nCoV infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan coronavirus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "Wuhan seafood market pneumonia virus infection",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "COVID19",
                        "description": ""
                    },
                    {
                        "id": "DOID:0080600",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0080600",
                        "name": "SARS-CoV-2 infection",
                        "description": ""
                    }
                ]
            },
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "32169400",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32169400"
                },
                {
                    "id": "32530509",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32530509"
                },
                {
                    "id": "32171076",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32171076"
                },
                {
                    "id": "32475810",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32475810"
                },
                {
                    "id": "32251612",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32251612"
                }
            ]
        }
    ],
    "publication": [
        {
            "title": "The role of biomarkers in diagnosis of COVID-19 - A systematic review.",
            "journal": "Life sciences",
            "authors": "Kermali M, Khalsa RK, Pillai K, Ismail Z, Harky A",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32475810",
                    "url": "https://glygen.org/publication/PubMed/32475810"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        },
        {
            "title": "Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.",
            "journal": "Lancet (London, England)",
            "authors": "Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32171076",
                    "url": "https://glygen.org/publication/PubMed/32171076"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        },
        {
            "title": "Cardiac troponin I in patients with coronavirus disease 2019 (COVID-19): Evidence from a meta-analysis.",
            "journal": "Progress in cardiovascular diseases",
            "authors": "Lippi G, Lavie CJ, Sanchis-Gomar F",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32169400",
                    "url": "https://glygen.org/publication/PubMed/32169400"
                }
            ],
            "evidence": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        },
        {
            "title": "Association of cardiac biomarkers and comorbidities with increased mortality, severity, and cardiac injury in COVID-19 patients: A meta-regression and decision tree analysis.",
            "journal": "Journal of medical virology",
            "authors": "Toraih EA, Elshazli RM, Hussein MH, Elgaml A, Amin M, El-Mowafy M, El-Mesery M, Ellythy A, Duchesne J, Killackey MT, Ferdinand KC, Kandil E, Fawzy MS",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
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                }
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                    "url": "https://data.glygen.org/GLY_000625"
                }
            ]
        },
        {
            "title": "High-Sensitivity Cardiac Troponin Can Be an Ally in the Fight Against COVID-19.",
            "journal": "Circulation",
            "authors": "Chapman AR, Bularga A, Mills NL",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32251612",
                    "url": "https://glygen.org/publication/PubMed/32251612"
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    "biomarker_id": "A0065",
    "aclist": [
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